40861-57-2Relevant academic research and scientific papers
Reductive Desilanolation as a Route to Benzonitriles. An Application to a Concise Synthesis of the Aromatic Sector of Calicheamicin.
Olson, Steven H.,Danishefsky, Samuel J.
, p. 7901 - 7904 (2007/10/02)
The TMS-cyanohydrins of quinones undergo reductive desilanolation in the presence of samarium iodide to form hydroxybenzonitriles.Benzoquinone 1 was converted to the hexasubstituted aromatic fragment of calicheamicin 4 by this method.
A Facile Synthesis of Cyanohydrin Trimethylsilyl Ethers by the Addition Reaction of Trimethylsilyl Cyanide with Aldehydes under Basic Condition
Kobayashi, Shu,Tsuchiya, Yoshikazu,Mukaiyama, Teruaki
, p. 537 - 540 (2007/10/02)
In the presence of a catalytic amount of Lewis base such as amine, phosphine, arsine or antimony, trimethylsilyl cyanide (TMS-CN) smoothly reacts with aldehydes to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent yields.
Efficient Solid Catalyst Systems for Cyanosilylation of Carbonyl Compounds with Cyanotrimethylsilane
Onaka, Makoto,Higuchi, Katsumi,Sugita, Keisuke,Izumi, Yusuke
, p. 1393 - 1396 (2007/10/02)
Clay montmorillonite, calcium fluoride, and hydroxyapatite are found to be effective solid catalysts for the reactions of cyanotrimethylsilane with carbonyl compounds.Different catalytic functions of the solid catalysts are also elucidated.
