40867-51-4

Basic information

• Product Name: Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester
• Synonyms: Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester
• CAS NO: 40867-51-4
• Molecular Weight: 332.356
• Mol File: 40867-51-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester(40867-51-4)
• EPA Substance Registry System: Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester(40867-51-4)

Safety Data

• Hazardous Substances Data: 40867-51-4(Hazardous Substances Data)

Upstream product

• 1600-27-7 mercury(II) diacetate 
• 1098-87-9 penicillin V sodium salt 
• 64-19-7 acetic acid 

Downstream Products

• 35592-67-7 (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one 

Relevant articles and documents

Syntheses and biological evaluations of highly functionalized hydroxamate containing and N-methylthio monobactams as anti-tuberculosis and β-lactamase inhibitory agents

Both the resurgence of tuberculosis (TB) and antibiotic resistance continue to threaten modern healthcare and new means of combating pathogenic bacterial infections are needed. The syntheses of monobactams possessing hydroxamate and N-methylthio functionality are described, as well as their anti-TB, in vitro β-lactamase inhibitory, and general antimicrobial evaluations. A number of compounds exhibited significant anti-TB and β-lactamase inhibitory activity, with MIC values in the range of 25 to i values in the range of 25-0.03 μM against purified NDM-1 and VIM-1 lystate metallo β-lactamases. This work suggests that these scaffolds may serve as promising leads in developing new antibiotics and/or β-lactamase inhibitors.