35592-67-7

Basic information

• Product Name: (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one
• Synonyms: (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one
• CAS NO: 35592-67-7
• Molecular Weight: 278.265
• Mol File: 35592-67-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one(35592-67-7)
• EPA Substance Registry System: (3S,4S)-4-acetoxy-3-phenoxyacetamido-azetidin-2-one(35592-67-7)

Safety Data

• Hazardous Substances Data: 35592-67-7(Hazardous Substances Data)

Upstream product

• 40867-51-4 Acetic acid (2S,3S)-1-(2-methyl-propenyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester 
• 1098-87-9 penicillin V sodium salt 
• 75666-47-6 (3S,4S)-3-benzyloxycarbonylamino-4-acetoxy-azetidin-2-one 
• 87-08-1 penicillin-V 
• 101651-14-3 amino-4-acetoxy-azetidin-2-one 
• 701-99-5 Phenoxyacetyl chloride 

Downstream Products

• 83169-17-9 (3R,4S)-4-ethylthio-3-phenoxyacetamido-2-oxoazetidine 
• 107740-83-0 C₁₆H₃₆N⁽¹⁺⁾*C₁₃H₁₃N₂O₈S₂^(1-) 
• 107645-12-5 C₁₃H₁₃N₂O₈S₂^(1-)*Na⁽¹⁺⁾ 
• 82801-36-3 [(2R,3R)-2-Allyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 82792-78-7 [(2R,3R)-2-Allyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-hydroxy-acetic acid 4-nitro-benzyl ester 
• 82792-76-5 (5R,6R)-7-Oxo-6-(2-phenoxy-acetylamino)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 107668-50-8 (2S,6R,7S)-benzyl-4-ethyl-8-oxo-7-phenoxyacetamido-5-oxa-1,3-diaza-bicyclo<4.2.0>oct-3-ene-2-carboxylate 
• 107668-48-4 (3S,4R)-1--3-phenoxyacetamido-4-prop-1-enyloxyazetidin-2-one 

Relevant articles and documents

Syntheses and biological evaluations of highly functionalized hydroxamate containing and N-methylthio monobactams as anti-tuberculosis and β-lactamase inhibitory agents

Both the resurgence of tuberculosis (TB) and antibiotic resistance continue to threaten modern healthcare and new means of combating pathogenic bacterial infections are needed. The syntheses of monobactams possessing hydroxamate and N-methylthio functionality are described, as well as their anti-TB, in vitro β-lactamase inhibitory, and general antimicrobial evaluations. A number of compounds exhibited significant anti-TB and β-lactamase inhibitory activity, with MIC values in the range of 25 to i values in the range of 25-0.03 μM against purified NDM-1 and VIM-1 lystate metallo β-lactamases. This work suggests that these scaffolds may serve as promising leads in developing new antibiotics and/or β-lactamase inhibitors.

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or Beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

STUDIES ON THE REACTIVITY OF 4-ACETOXY-3-ACYLAMINO-2-AZETIDINONES: STEREOSPECIFIC trans CARBON-CARBON BOND FORMATION

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