35592-67-7Relevant academic research and scientific papers
Syntheses and biological evaluations of highly functionalized hydroxamate containing and N-methylthio monobactams as anti-tuberculosis and β-lactamase inhibitory agents
Majewski, Mark W.,Watson, Kyle D.,Cho, Sanghyun,Miller, Patricia A.,Franzblau, Scott G.,Miller, Marvin J.
supporting information, p. 141 - 147 (2016/01/30)
Both the resurgence of tuberculosis (TB) and antibiotic resistance continue to threaten modern healthcare and new means of combating pathogenic bacterial infections are needed. The syntheses of monobactams possessing hydroxamate and N-methylthio functionality are described, as well as their anti-TB, in vitro β-lactamase inhibitory, and general antimicrobial evaluations. A number of compounds exhibited significant anti-TB and β-lactamase inhibitory activity, with MIC values in the range of 25 to i values in the range of 25-0.03 μM against purified NDM-1 and VIM-1 lystate metallo β-lactamases. This work suggests that these scaffolds may serve as promising leads in developing new antibiotics and/or β-lactamase inhibitors.
1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION
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, (2008/06/13)
Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R is hydrogen, R or R4 where R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals
1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION
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, (2011/08/10)
Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or Beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals
REACTIONS OF (2-OXO-1-AZETIDINYL)-THIOPHTHALIMIDES WITH NUCLEOPHILES
Iwagami, Hisao,Woulfe, Steven R.,Miller, Marvin J.
, p. 3095 - 3098 (2007/10/02)
Reaction of the title compounds with a variety of oxygen, nitrogen, carbon and sulfur nucleophiles proceeds by direct attack at the sulfur atom to provide novel substituted N-thio-2-azetidinones.
Cephalosporin analogues and compositions
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, (2008/06/13)
Novel cephalosporin analogues, salts and esters thereof, their preparation, intermediates and antibacterial compositions containing them. The compositions are formulated for human use into unit dosage form containing 100-4,000 mg of antibacterial compound. The cephem analogues are characterized by having a ring O-heteroatom instead of a ring N-heteroatom and are designated as oxacephems.
