40900-00-3Relevant academic research and scientific papers
Substrate-Controlled Regioselective Arylations of 2-Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3′-Bisindole Derivatives
He, Ying-Ying,Sun, Xiao-Xue,Li, Guo-Hao,Mei, Guang-Jian,Shi, Feng
, p. 2462 - 2471 (2017)
A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been established, which efficiently afforded bis(indolyl)methane and 3,3′-bisindole derivatives in high yields and with a broad substrate scope (up to 98% yield, 36 examples). This approach will not only provide an important strategy for the diversified synthesis of bis(indolyl)methane and 3,3′-bisindole derivatives but also serve as a good example for substrate-controlled regioselective reactions.
Benzannulation of 2-Alkenylindoles using Aldehydes by Sequential Triple-Relay Catalysis: A Route to Carbazoles and Carbazole Alkaloids
Banerjee, Ankush,Sahu, Samrat,Maji, Modhu Sudan
supporting information, p. 1860 - 1866 (2017/06/09)
Benzannulation of 2-alkenylindoles with readily available aldehydes, under one-pot sequential triple-relay-catalysis, provides an easy access to several structurally unique carbazoles including 2- and 3-alkenylcarbazoles. This protecting group-free method enabled one-pot synthesis of alkaloids such as hyellazole and 6-chlorohyellazole, and the formal syntheses of seven other alkaloids. Construction of the core structure, present in murastifoline A, murrafoline E, and related alkaloids was also demonstrated. Even conjugated 3,3′-biscarbazoles can also be synthesized by one-pot, two-fold sequential triple-relay catalysis. (Figure presented.).
The N-tert-butylcarbamoyl directed metalation group for the regiospecific synthesis of 2-substituted pyrroles and indoles
Gharpure,Stoller,Bellamy,Firnau,Snieckus
, p. 1079 - 1082 (2007/10/02)
The N-tert-butylcarbamoyl serves as a useful, readily removable (LiOH/MeOH/THF) new directed metalation group for the synthesis of 2-substituted pyrroles and indoles.
