409060-11-3Relevant academic research and scientific papers
Synthesis and tautomerism of 2-[3(5)-aryl(methyl)pyrazol-4-yl]-1- benzimidazoles
Dzvinchuk,Lozinskii
, p. 1190 - 1196 (2008/09/20)
An efficient method has been developed for the synthesis of 2-[3(5)-aryl(methyl)pyrazol-4-yl]-1H-benzimidazoles by cyclocondensation of 2-acylmethyl-1H-benzimidazoles benzoylhydrazones with DMF dimethylacetal. The tautomerism of the compounds obtained via migrations of a proton between the pyrazole nitrogen atoms has been studied by 1H NMR. The more stable tautomers have electron acceptor aryl substituents placed at position 3 of the pyrazole ring and electron donor aryl substituents or a methyl at position 5. Springer Science+Business Media, Inc. 2006.
