409093-03-4

Upstream product

• 111-71-7 heptanal 
• 124156-21-4 ethyl (4-methoxyphenylimino)acetate 
• 115276-75-0 ethyl (E)-2-(p-methoxyphenylimino)acetate 
• 924-44-7 glyoxylic acid ethyl ester 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

Organocatalysis in Ionic Liquids: Highly Efficient L-Proline-Catalyzed Direct Asymmetric Mannich Reactions Involving Ketone and Aldehyde Nucleophiles

Proline-catalyzed direct asymmetric Mannich reactions of N-PMP protected α-imino ethyl glyoxylate with various aldehydes and ketones in ionic liquids afforded both α- and β-amino acid derivatives with excellent yields and enantioselectivities, providing f

List-Barbas-Mannich reaction catalyzed by modularly designed organocatalysts

The List-Barbas-Mannich reaction of ethyl (p-methoxyphenylimino)acetate (p-methoxyphenyl = PMP) with unmodified aldehydes or ketones catalyzed by modularly designed organocatalysts (MDOs) that are self-assembled from proline and cinchona alkaloid thiourea

Enantioselective organocatalytic mannich reactions with autocatalysts and their mimics

(Figure Presented) The Mannich reactions previously extensively investigated with organocatalysis of L-proline and other related small molecules were reinvestigated with detailed stereochemical analysis of their autocatalysis pathways, through employment

A solid-supported organocatalyst for highly stereoselective, batch, and continuous-flow mannich reactions

The fast and highly stereoselective Mannich reaction of aldehydes and ketones with the N-(p-meihoxyphenyl) ethyl glyoxylate imine catalyzed by polystyrene resins functionalized with (2S,4R)-hydroxyproline is reported. The effect of the nature of the linke

Pipecolic acid-catalyzed direct asymmetric Mannich reactions

Mannich reactions between aldehydes and N-p-methoxyphenyl-protected α-imino ethyl glyoxylate have been performed using (S)-pipecolic acid as catalyst. The reactions give both syn- and anti-products (dr = 1.4-2:1) with high enantioselectivities (>98% ee).

The Direct Catalytic Asymmetric Cross-Mannich Reaction: A Highly Enantioselective Route to 3-Amino Alcohols and α-Amino Acid Derivatives

The first proline-catalyzed direct catalytic asymmetric one-pot, three-component cross-Mannich reaction has been developed. The highly chemoselective reactions between two different unmodified aldehydes and one aromatic amine are new routes to 3-amino ald

The Direct Organocatalytic Asymmetric Mannich Reaction: Unmodified Aldehydes as Nucleophiles

The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct

Direct organocatalytic asymmetric Mannich-type reactions in aqueous media: One-pot Mannich-allylation reactions

The first direct organocatalytic asymmetric Mannich-type reactions in aqueous media are demonstrated herein. L-Proline-catalyzed reactions in aqueous media to provide β-formyl substituted α-amino acid derivatives with excellent diastereoselectivities (dr

A highly enantioselective route to either enantiomer of both α- and β-amino acid derivatives

This report describes the unprecedented use of unmodified aldehydes as donors in a catalytic asymmetric Mannich-type reaction. The proline-catalyzed reaction of N-PMP-protected α-imino ethyl glyoxylate with unmodified aliphatic aldehydes provided a genera

One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives: Formation of Three Contiguous Stereogenic Centers

(Matrix Presented) One-pot asymmetric Mannich-hydrocyanation reactions are described. Reaction of unmodified aldehydes with N-PMP-protected α-imino ethyl glyoxylate in the presence of catalytic amounts of L-proline followed by the addition of Et2/su