409093-07-8Relevant academic research and scientific papers
The Direct Organocatalytic Asymmetric Mannich Reaction: Unmodified Aldehydes as Nucleophiles
Notz, Wolfgang,Tanaka, Fujie,Watanabe, Shin-Ichi,Chowdari, Naidu S.,Turner, James M.,Thayumanavan, Rajeswari,Barbas III, Carlos F.
, p. 9624 - 9634 (2007/10/03)
The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct
A highly enantioselective route to either enantiomer of both α- and β-amino acid derivatives
Cordova, Armando,Watanabe, Shin-Ichi,Tanaka, Fujie,Notz, Wolfgang,Barbas III, Carlos F.
, p. 1866 - 1867 (2007/10/03)
This report describes the unprecedented use of unmodified aldehydes as donors in a catalytic asymmetric Mannich-type reaction. The proline-catalyzed reaction of N-PMP-protected α-imino ethyl glyoxylate with unmodified aliphatic aldehydes provided a genera
