4363-41-1 Usage
Description
(E)-2-Phenylethylenesulfonamide, also known as α-(phenylsulfonyl)acrylamide, is a chemical compound that features a sulfonamide functional group attached to a phenylethylene group. It is widely recognized for its role as a starting material in organic synthesis and for its potential biological activities, such as enzyme inhibition and anti-cancer properties. Furthermore, its unique structural characteristics have led to its use in developing new materials with specific optical and electronic properties.
Uses
Used in Organic Synthesis:
(E)-2-Phenylethylenesulfonamide is used as a starting material for the preparation of various heterocyclic compounds and drugs. Its versatile chemical structure allows for the creation of a broad range of pharmaceutically relevant molecules.
Used in Pharmaceutical Development:
(E)-2-Phenylethylenesulfonamide is used as a precursor in the development of new drugs. Its potential biological activities, such as acting as an enzyme inhibitor, make it a promising candidate for the treatment of various diseases.
Used in Cancer Research:
(E)-2-Phenylethylenesulfonamide is used as a compound with potential anti-cancer properties. It is being studied for its ability to target and inhibit specific enzymes or pathways involved in cancer cell growth and proliferation.
Used in Material Science:
(E)-2-Phenylethylenesulfonamide is used in the development of new materials with specific optical and electronic properties. Its unique structure contributes to the creation of materials with tailored characteristics for various applications in technology and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 4363-41-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,6 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4363-41:
(6*4)+(5*3)+(4*6)+(3*3)+(2*4)+(1*1)=81
81 % 10 = 1
So 4363-41-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-7H,(H2,9,10,11)/b7-6+
4363-41-1Relevant articles and documents
Designing anti-inflammatory drugs from parasitic worms: A synthetic small molecule analogue of the acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis
Al-Riyami, Lamyaa,Pineda, Miguel A.,Rzepecka, Justyna,Huggan, Judith K.,Khalaf, Abedawn I.,Suckling, Colin J.,Scott, Fraser J.,Rodgers, David T.,Harnett, Margaret M.,Harnett, William
, p. 9982 - 10002 (2014/01/17)
In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is unsuitable for use as a drug. Following preliminary in vitro screening for inhibitory effects on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testing in an in vivo model of inflammation, collagen-induced arthritis (CIA). Testing revealed that 11a was as effective as ES-62 in protecting DBA/1 mice from developing CIA and mirrored its mechanism of action in downregulating the TLR/IL-1R transducer, MyD88. 11a is thus a novel prototype for anti-inflammatory drug development.
