4091-91-2

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLORO-1-PHENOTHIAZIN-10-YL-PROPAN-1-ONE is used as a key intermediate in the synthesis of various substituted phenothiazines and their derivatives. These compounds have a wide range of pharmaceutical applications, including the development of drugs for the treatment of various disorders such as schizophrenia, bipolar disorder, and other mental health conditions. The chloroacetyl group in 3-CHLORO-1-PHENOTHIAZIN-10-YL-PROPAN-1-ONE allows for further chemical modifications, enabling the creation of novel therapeutic agents with improved pharmacological properties.

InChI:InChI=1/C15H12ClNOS/c16-10-9-15(18)17-11-5-1-3-7-13(11)19-14-8-4-2-6-12(14)17/h1-8H,9-10H2

Upstream product

• 92-84-2 10H-phenothiazine 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 3576-44-1 10-(N,N-dimethyl-β-alanyl)-10H-phenothiazine 
• 1104951-47-4 10-{2-[N-(L-ephedrino)]propionyl}phenothiazine 
• 5909-59-1 10-(3-chloropropyl)-10H-phenothiazine 

Relevant academic research and scientific papers

Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells

Two novel series of 1,2,3-triazole?phenothiazine hybrids and dithiocarbamate?phenothiazine hybrids were designed and synthesized by molecular hybridization strategy. Their antiproliferative activity against three gastric cancer cell lines (MKN28, MGC-803

Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study

The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.

Synthesis and antifungal activity of some substituted phenothiazines and related compounds

Several phenothiazines and related compounds were synthesized and their antifungal activity was evaluated in vitro. The results observed for α-chloro-N-acetyl phenothiazine led us to choose this compound as a lead in the search of antifungal agents.

Synthesis of N-alkaloidacyl derivatives of phenothiazine

Compounds in which cytisine, anabasine, D-pseudoephedrine, and L-ephedrine fragments are linked to the phenothiazine nitrogen atom via acyl group were synthesized. These compounds are potential drugs, and their activity was confirmed by computer prediction using PASS software.

N-Homolupinanoyl and N-(ω-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes

A set of N-homolupinanoyl- and N-(ω-lupinylthio)alkanoyl derivatives of tricyclic systems (as phenothiazine, iminodibenzyl and dihydropyridobenzodiazepinone) has been prepared and tested for affinity for rat muscarinic M1 and M2 receptor subtypes labeled with [3H]pirenzepine and [3H]AF-DX 384. Good affinity for both M1 and M2 subtypes was displayed by most compounds, often with nanomolar Ki values, which for lupinylthiopropionyl- and lupinylthiobutyryl-phenothiazines (13-16) were comparable to those of pirenzepine and methoctramine, respectively. However, only moderate selectivity for one or the other subtype was seen.