409334-96-9Relevant academic research and scientific papers
Photocatalytic Reductive Formation of α-Tertiary Ethers from Ketals
Rossolini, Thomas,Ferko, Branislav,Dixon, Darren J.
, p. 6668 - 6673 (2019)
A general photocatalytic reductive strategy for the construction of unsymmetrical α-tertiary dialkyl ethers is reported. By merging Lewis acid-mediated ketal activation and visible-light photocatalytic reduction, in situ-generated α-alkoxy radicals were found to engage in addition reactions with a variety of olefinic partners. Good reaction efficiency is demonstrated with a range of ketals of aromatic and aliphatic ketones. Extension to acetal substrates is also described, demonstrating the overall synthetic utility of this methodology for complex ether synthesis.
CuH-catalyzed enantioselective intramolecular reductive aldol reactions generating three new contiguous asymmetric stereocenters
Lipshutz, Bruce H.,Amorelli, Benjamin,Unger, John B.
supporting information; experimental part, p. 14378 - 14379 (2009/02/08)
Treatment of β,β-disubstituted-α,β-unsaturated ketones bearing a ketone residue with in situ generated, catalytic CuH ligated by a nonracemic ligand leads to three newly created adjacent chiral centers. Excellent des and ees are obtained for several examples studied. Copyright
