40943-37-1

Basic information

• Product Name: N-METHOXYCARBONYL-O-METHYLISOUREA
• Synonyms: N-METHOXYCARBONYL-O-METHYLISOUREA;methyl (iminomethoxymethyl)-carbamate;N-METHOXYCARBONYL-2-METHYLISOUREA;[Methoxy(amino)methylene]carbamic acid methyl ester;N-[Imino(methoxy)methyl]carbamic acid methyl ester
• CAS NO: 40943-37-1
• Molecular Formula: C₄H₈N₂O₃
• Molecular Weight: 132.12
• EINECS: 255-150-1
• Mol File: 40943-37-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.22g/cm³
• Refractive Index: 1.458
• PKA: 8.77±0.46(Predicted)
• CAS DataBase Reference: N-METHOXYCARBONYL-O-METHYLISOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXYCARBONYL-O-METHYLISOUREA(40943-37-1)
• EPA Substance Registry System: N-METHOXYCARBONYL-O-METHYLISOUREA(40943-37-1)

Safety Data

• Hazardous Substances Data: 40943-37-1(Hazardous Substances Data)

Usage

General Description

N-Methoxycarbonyl-O-methylisourea is a chemical compound with the molecular formula C5H9NO4. It is a white solid that is commonly used as a reagent in organic synthesis, particularly in the preparation of pharmaceuticals. N-METHOXYCARBONYL-O-METHYLISOUREA is known for its ability to selectively react with aldehydes and ketones to form 1,3-oxazolidin-2-ones, which are important intermediate compounds in the synthesis of various pharmaceuticals and other organic molecules. N-Methoxycarbonyl-O-methylisourea is also used in the preparation of peptide and protein derivatives, as well as in the modification of functional groups in organic molecules. Overall, this compound has significant utility in the field of organic chemistry and pharmaceutical research due to its reactivity and versatility in synthesizing complex molecules.

InChI:InChI=1/C4H8N2O3/c1-8-4(7)6-3-9-2-5/h2,5H,3H2,1H3,(H,6,7)

Upstream product

• 104-12-1 p-chlorphenylisocyanate 
• 5329-33-9 o-methylisourea hydrochloride 
• 79-22-1 methyl chloroformate 
• 24285-39-0 O-methylisourea hydrosulfate 
• 29427-58-5 O-methylisourea hemisulfate 

Downstream Products

• 31430-15-6 flubendazole 
• 122558-91-2 methyl [5-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazol-2-yl]carbamate 
• 136722-79-7 (+)-(S)-methyl <9-chloro-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo<4,5,1-jk><1,4>benzodiazepin-2-yl>carbamate 
• 31431-39-7 mebendazole 
• 54965-21-8 Albendazole 
• 53626-78-1 methyl 4-(p-chlorophenyl)-N-methoxycarbonyl allophanimidate 

Relevant articles and documents

O-methyl-isourea carboxylic acid methyl ester preparation

The invention discloses a method for preparing O-methyl isourea methyl formate. According to the method, O-methyl isourea bisulfate and methyl chloroformate are put in the mixed solvent of chloroform-water or toluene-water and the like, and O-methyl isourea methyl formate is prepared under alkaline conditions. The method has no step of synthesizing O-methyl isourea sulfate, the production period is shortened, the energy consumption is reduced, the labor intensity of workers is reduced, and the production capacity is improved; the product cost is reduced and the environmental pollution is reduced due to no use of methanol and sodium hydroxide in the method; the water amount in the mixed solvent is strictly controlled, large water amount results in low yield due to large solubility of the product in water; small water amount results in difficult separation of the product due to poor dissolution of inorganic salts produced by the reaction; and the yield is improved by 1-2 percent.

Substituted 1,2,4,6-Thiatriazine 1,1-Dioxides, their Synthesis and Structure

N2-(Methoxycarbonyl)amidines 4 and analogously substituted O-(alkyl)isoureas 5 yield, on reaction with N-alkylsulfamic chlorides, sulfamides 6 and 7 which can be cyclized to give 1,2,4,6-thiatriazin-3-one 1,1-dioxides 8 or 9, respectively.Their structural assignment - with regard to the position of the acidic hydrogen - is supported by X-ray analysis of 9a.The compounds 8 and 9 show herbicidal activity.

Methods for increasing rice crop yields

A method for increasing the yield of rice crops involving application of an s-triazinedione such as 3-(4-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H)-dione to the seed, seedlings, or soil in which the seed or seedlings are planted.