40958-96-1Relevant academic research and scientific papers
A novel and facile reaction to N6-alkylated adenosine via benzotriazole as a synthetic auxiliary
Afify, Hanan M. N. M.,Pedersen, Erik B.,Zahran, Magdy A.
, p. 339 - 341 (2000)
The reaction of benzotriazole with aliphatic, aromatic or heteroaromatic aldehyde and adenosine leads to a benzotriazole adduct which is reduced with sodium borohydride to the corresponding N6-alkylated adenosine derivatives. This procedure is also utilized in a new route to N6-(3- iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) which is considered an important adenosine agonist at A3 adenosine receptors.
