Journal of Heterocyclic Chemistry p. 339 - 341 (2000)
Update date:2022-08-05
Topics:
Afify, Hanan M. N. M.
Pedersen, Erik B.
Zahran, Magdy A.
The reaction of benzotriazole with aliphatic, aromatic or heteroaromatic aldehyde and adenosine leads to a benzotriazole adduct which is reduced with sodium borohydride to the corresponding N6-alkylated adenosine derivatives. This procedure is also utilized in a new route to N6-(3- iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) which is considered an important adenosine agonist at A3 adenosine receptors.
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