41011-08-9

Upstream product

• 28480-70-8 5'-chloro-2'-hydroxy-4'-methyl acetophenone 
• 100-52-7 benzaldehyde 
• 54963-43-8 4-chloro-3-methylphenyl acetate 
• 59-50-7 4-Chloro-3-methylphenol 

Downstream Products

• 1318918-47-6 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-phenyl-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline 
• 147919-55-9 6-Chloro-7-methyl-2-phenyl-chroman-4-one 

Relevant academic research and scientific papers

6-Chloro-7-methyl-3', 4'-dimethoxyflavone - a potent selective COX-2 inhibitor

Some unnatural chalcones (1a-q) and flavones (2a-d) have been synthesized and evaluated for their antiinflammatory activity using carrageenan-induced rat paw edema assay. The flavone 2c (6-Chloro-7-methyl-3', 4'- dimethoxyflavone) had higher anti-inflamma

Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents

Thirteen new 2-pyrazoline derivatives bearing benzenesulfonamide moiety (2a-m) were synthesized by condensing appropriate chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride and tested for anticancer and anti-inflammatory actions. According to the

Solution phase photocyclisation reaction of 2-hydroxychalcones to 4-flavanones

The photochemical cyclisation of 2-hydroxychalcones leading to the synthesis of 4-flavanones in solution phase has been investigated. The formation of photoproducts has been explained on the basis of excited state intramolecular proton transfer (ESIPT) and the cyclisation efficiency of the chalcones has been found to depend upon the electron density on the phenolic oxygen as well as on the carbonyl group. This synthesis of flavanones by photoirradiation is an eco-friendly route with comparative yield to those of thermal methods. Although the molecular skeletons of these substrates is amenable to cis-trans isomerisations and cycloadditions but no photoproducts corresponding to these reactions have been realized.

New synthesis of flavanones catalyzed by L-proline

L-Proline is utilized as an efficient organocatalyst for the synthesis of substituted flavanones and chalcones in good yields. The efficiency of the catalyst was proved with a variety of substrates ranging from electron-deficient to electron-rich aryl aldehydes and 2-hydroxyacetophenones.

Synthesis of some benzothiazepins and their antimicrobial activities

A series of 2-[(substitutedphenyl)-4-(substitutedphenyl)]-3,3-dihydro substituted-1,5-benzothiazepin 3 has been synthesized starting from acetophenones. The compounds are characterized and screened for their antimicrobial activities.