41024-33-3

Usage

Uses

Used in Organic Synthesis:
ALPHA-BROMO-3-CHLOROBENZENEACETIC ACID ETHYL ESTER is used as a synthetic intermediate for the production of various organic compounds. Its unique structure, featuring both a bromo and chloro group on the benzene ring, allows for versatile chemical reactions and modifications, making it a valuable component in the synthesis of a range of chemical products.
Used as a Precursor in Chemical Production:
In the chemical industry, ALPHA-BROMO-3-CHLOROBENZENEACETIC ACID ETHYL ESTER serves as a precursor for the synthesis of other chemical compounds. Its functional groups can be further reacted or modified to produce desired end products, contributing to the development of new materials and substances with specific applications.
Note: Since the provided materials do not specify different industries or more detailed applications, the uses listed are general and based on the information given. If more specific applications or industries are identified in further research or materials, they can be added to the list accordingly.

InChI:InChI=1/C10H10BrClO2/c1-2-14-10(13)9(11)7-4-3-5-8(12)6-7/h3-6,9H,2H2,1H3

Upstream product

• 54395-28-7 ethyl 2-(3-chlorophenyl)-2-hydroxyacetate 
• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 1398179-38-8 ethyl 2-(3-chlorophenyl)-2-diazoacetate 
• 587-04-2 m-Chlorobenzaldehyde 
• 100948-25-2 2-(3-chlorophenyl)-2-(trimethylsilyloxy)acetonitrile 

Downstream Products

• 66503-96-6 (1R,2S)-1-(3-Chloro-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 869347-30-8 (+/-)-α-(3-chlorophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester 
• 1438263-68-3 C₁₅H₁₃ClO₅ 
• 287393-09-3 ethyl (3-chlorophenyl)[(4-hydroxyphenyl)sulfanyl] acetate 
• 869347-35-3 (+/-)-α-ethyl-α-(3-chlorophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester 
• 869347-40-0 (+/-)-α-ethyl-α-(3-chlorophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid 

Relevant academic research and scientific papers

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).

Pd-catalyzed divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates

A Pd-catalyzed site-selective C(sp2)-H activation/cycloimidoylation of 2-isocyano-2,3-diarylpropanoates to construct diverse cyclic imine products has been developed. Six-membered 3,4-dihydroisoquinolines containing a C3 quaternary carbon cente

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

The design, synthesis, and antiplasmodial activity of antimalarial heterodimers based on the 1,4-bis(3-aminopropyl)piperazine linker is reported. In this series key structural elements derived from quinoline antimalarials were coupled to fragments capable

Method of treating depression using azabicyclohexanes

The present invention concerns certain novel substituted 3-azabicyclo[3.1.0]hexanes and a method of treating depression and stress in a warm-blooded animal, comprising the administration of substituted 3-azabicyclo[3.1.0]hexanes.

1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents

A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.

Azabicyclohexanes

Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.