100948-25-2

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 587-04-2 m-Chlorobenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 97070-75-2 (S)-(-)-2-hydroxy-2-(3-chlorophenyl)acetonitrile 
• 122047-10-3 (R)-(+)-2-hydroxy-2-(3-chlorophenyl)acetonitrile 
• 1039167-23-1 (R)-2-[2-(3-Chloro-phenyl)-2-oxo-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 82128-89-0 5-(3-chlorophenyl)oxazolidine-2,4-dione 
• 41024-33-3 (+/-)-α-bromo-(3-chlorophenyl)acetic acid ethyl ester 
• 721428-23-5 1-(3-benzyloxy-phenyl)-2-(3-chloro-phenyl)-ethane-1,2-dione 
• 721428-21-3 2-(3-benzyloxyphenyl)-1-(3-chlorophenyl)-2-hydroxyethan-1-one 
• 97070-75-2 2-(3-chlorophenyl)-2-hydroxyacetonitrile 
• 49704-72-5 α-amino-(3-chlorophenyl)acetonitrile hydrochloride 
• 16273-37-3 3-chloromandelic acid 
• 82128-88-9 3-chloro-mandelimidic acid ethyl ester; hydrochloride 
• 54395-28-7 ethyl 2-(3-chlorophenyl)-2-hydroxyacetate 
• 124862-62-0 2-acetoxy-2-(3-chlorophenyl)acetonitrile 

Relevant academic research and scientific papers

Multinuclear transition metal-containing polyoxometalates constructed from Nb/W mixed-addendum precursors: synthesis, structures and catalytic performance

Four new transition metal-containing Nb/W mixed-addendum POM trimers with the formula H19[M4(H2O)x(P2W15Nb3O62)3]·m(HCOOH)·nH2O (M = Cu,x= 15,m=

Perfectly green organocatalysis: Quaternary ammonium base triggered cyanosilylation of aldehydes

Quaternary ammonium bases, such as aqueous (CH3)4NOH, were found to be an extraordinarily efficient catalyst for cyanosilylation of aldehydes. The addition reaction of trimethylsilyl cyanide (TMSCN) to equivalent aldehydes could proceed smoothly with turnover frequency (TOF) up to 3000000 h-1 and in near 100% yield under solvent-free conditions. These organic catalysts also tolerated various aldehydes including aromatic, aliphatic and α,β-unsaturated aldehydes. This process perfectly conforms to the features of green chemistry: no waste regarding side-products and unconverted reactants, solvent-free, excellent catalytic activity, and no requirement for separation.

Asymmetric cyanosilylation of aldehydes catalyzed by novel organocatalysts

A novel proline-based N,N′-dioxide, which is easily prepared from inexpensive chemicals, serves as an effective catalyst for enantioselective cyanosilylation of aldehydes in up to 73% ee. Georg Thieme Verlag Stuttgart.

Kinetics and mechanism of the racemic addition of trimethylsilyl cyanide to aldehydes catalysed by Lewis bases

The mechanism by which four Lewis bases, triethylamine, tetrabutylammonium thiocyanate, tetrabutylammonium azide and tetrabutylammonium cyanide, catalyse the addition of trimethylsilyl cyanide to aldehydes is studied by a combination of kinetic and spectr

Efficient synthesis of cyanohydrin trimethylsilyl ethers via 1,2-chemoselective cyanosilylation of carbonyls

Here we report a sustainable protocol for the cyanosilylation of carbonyl compounds 1a-g and 3a-m using trimethylsilyl cyanide and triphenylphosphine supported on polystyrene as a catalyst under solvent-free conditions. It has been shown that a small amou

Porous Co-MOF for cyanosilylation reaction and protective effect in child bronchial pneumonia by reducing the inflammatory response and IL-12 production in immune cells

A new porous metal–organic framework (MOF) with the chemical formula of [Co2(FDDI)(H2O)3](DMA)4 (1, H4FDDI = 5,5′-(9H-fluorene-2,7-diyl) showing the ttd-type topological structure has been prepared by

PhI(OAc)2-mediated alkoxyoxygenation of β,γ-unsaturated ketoximes: Preparation of isoxazolines bearing two contiguous tetrasubstituted carbons

A PhI(OAc)2-promoted dioxygenation of allyl oximes, including one alkoxylation, has been developed. This reaction can give isoxazoline products bearing two contiguous tetrasubstituted carbons. Various oximes substrates bearing different aryl groups and tetrasubstituted-olefin moieties were compatible with the mild reaction conditions. A two-electron oxidation pathway was proposed based on results of preliminary mechanistic studies.

Method for aldehyde cyanosilylation reaction under conditions of no catalyst or solvent

The invention discloses a method for an aldehyde cyanosilylation reaction under conditions of no catalyst or solvent. In a glove box, aldehyde and trimethylsilyl cyanide are sequentially added to a nuclear magnetic resonance tube, then, the glove box is m

Hydroxynitrile Lyase Isozymes from Prunus communis: Identification, Characterization and Synthetic Applications

Biocatalysts originating from Badamu (Prunus communis) have been applied to catalyze the asymmetric synthesis of (R)-4-methylsulfanylmandelonitrile, a key building block of thiamphenicol and florfenicol. Here, four hydroxynitrile lyase (HNL) isozymes from Badamu were cloned and heterologously expressed in Pichia pastoris. The biochemical properties and catalytic performances of these isozymes were comprehensively explored to evaluate their efficiency and selectivity in asymmetric synthesis. Among then, PcHNL5 was identified with outstanding activity and enantioselectivity in asymmetric hydrocyanation. Under the optimized mild biphasic reaction conditions, seventeen prochiral aromatic aldehydes were converted to valuable chiral cyanohydrins with good yields (up to 94%) and excellent optical purities (up to >99.9% ee), which provide a facile access to numerous chiral amino alcohols, hypoglycemic agents, angiotension converting enzyme (ACE) inhibitors and β-blockers. This work therefore underlines the importance of discovering the most potent biocatalyst among a group of isozymes for converting unnatural substrates into value-added products. (Figure presented.).

The application of spontaneous flocculation for the preparation of lanthanide-containing polyoxometalates intercalated layered double hydroxides: highly efficient heterogeneous catalysts for cyanosilylation

The lanthanide-containing polyoxometalates (POMs) have been intercalated into layered double hydroxides (LDHs) successfully through the spontaneous flocculation method, resulting in the formation of new heterogeneous LDHs–POMs catalysts Mg3Al–L