41024-87-7

Upstream product

• 54533-84-5 2-(2-(2-chloroethoxy)ethoxy)tetrahydro-2H-pyran 
• 120-80-9 benzene-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 41757-99-7 1,2-bis[2-(2-hydroxyethoxy)ethoxy]benzene 

Downstream Products

• 54533-82-3 2,3-benzo-10-tosyl-10-aza-1,4,7,13-tetraoxa-2-cyclopentadecene 
• 85725-87-7 11-benzyloxymethyl-2,3-benzo-18-crown-6 
• 157769-17-0 1,3-calix[4]bis-o-benzocrown-6 
• 321985-37-9 C₆₀H₆₂O₁₂ 
• 86210-61-9 Toluene-4-sulfonic acid 6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-12-ylmethyl ester 
• 54533-83-4 benzo-10-aza-15-crown-5 
• 892844-88-1 1,2-bis-[2-(2-iodo-ethoxy)-ethoxy]-benzene 
• 865201-03-2 C₆₈H₇₆O₁₅ 

Relevant academic research and scientific papers

Strong induced-fit binding of viologen and pyridine derivatives in adjustable porphyrin cavities

The synthesis and binding properties of new porphyrin cage compounds consisting of a rigid diphenylglycoluril part, which is connected via flexible bis(ethyleneoxy) spacers to a (metallo)porphyrin "roof", are reported. Binding of viologen guests and pyrid

The crown ether size and stereochemistry affect the self-assembly, hydrogelation, and cellular interactions of crown ether/peptide conjugates

The discovery of crown ethers and their unique interactions with ions make them play a key role in supramolecular chemistry. In this study, we have developed a new type of amphiphilic crown ether (DB18C6, DB24C8)-conjugated phenylalanine dipeptides for th

Catechol ether chain bridged diureido pyrimidone compound and synthesizing method thereof

The invention provides a catechol ether chain bridged diureido pyrimidone compound and a synthesizing method, and relates to a compound and a synthesizing method thereof. The compound is an ether chain bridged diureido pyrimidone compound based on condens

Synthesis of Novel Di Benzo spiro bis-crown-ether

This paper focuses on the synthesis of a wide variety of di benzo spiro bis-crown compounds, in good yields using di-phenols, mono tosylates of oligoethylene glycols and caesium carbonate in acetonitrile.

Synthesis of enantiopure P-stereogenic diphosphacrowns using P-stereogenic secondary phosphines

A new synthetic route to enantiopure P-stereogenic benzodiphosphacrowns using a P-stereogenic secondary bisphosphine as the key building block is reported. Syntheses of the enantiomer and P-stereogenic crowns with various ring structures, as well as debor

Competitive binding of Ba2+and Sr2+ to 18-crown-6 in a receptor with a 1-methoxyanthraquinone analogue as the other binding site

Owing to their immense biological significance, development of sensors for the selective detection of alkaline earth metal ions has attracted vast research interest. In this article we have reported the synthesis, characterisation and ion binding studies of a new RuII-polypyridyl-crown-anthraquinone complex (5). Studies confirm selective binding of BaII, Sr II and CaII ions, with KaBaa2+ > KaSra2+ >> KaCaa2+, over all other metal ions, to the crown ether moiety and not to the methoxy anthraquinone component, the latter being the second binding site available and known for its affinity towards alkaline earth metal ions from one of our previous reports. A new RuII-polypyridyl complex with two probable binding sites for metal ions has been synthesised to which Ca2+, Sr2+ and Ba2+ were found to bind selectively over all other alkali, alkaline earth, transition and lanthanide metal ions. Studies also confirmed binding of these metal ions solely to the 18-crown-6 and not to the methoxyanthraquinone moiety known to bind alkaline earth metal ions. Copyright

Mono-ionizable calix[4]arene-benzocrown-6 ligands in 1,3-alternate conformations: synthesis, structure and silver(I) extraction

Two series of novel mono-ionizable calix[4]arene-benzocrown-6 ligands in 1,3-alternate conformations are synthesized. In one series, the proton-ionizable group (PIG) is attached to the para position of one aromatic ring in the calixarene framework, thereby positioning it over the polyether ring cavity. In the other series, the PIG is a substituent on the benzo group in the polyether ring. This orients the PIG away from the crown ether cavity. In addition to carboxylic acid functions, the PIGs include N-(X)sulfonyl carboxamide groups. With X group variation from methyl to phenyl to 4-nitrophenyl to trifluoromethyl, the acidity of the PIG is 'tuned'. Solvent extraction of Ag+ from aqueous solutions into chloroform is used to probe the influence of structural variation within the mono-ionizable calixcrown ligand on metal ion extraction efficiency, including the identity and acidity of the PIG and its orientation with respect to the polyether ring.

Novel synthesis of macrocycles with 1,1′-binaphthalene-2,2′-diol using intramolecular oxidative coupling

A new series of BINOL-based macrocycles with two phenolic protons have been synthesized via oxidative coupling reaction using CuCl(OH)-TMEDA.

New crown-carrier Cα,α-disubstituted glycines derived from α-methyl-(L)-DOPA

The side-chain catechol function of α-methyl-(L)-DOPA was utilized for the synthesis of a new series of crown-carrier Cα,α-disubstituted glycines. During N-protection of α-methyl-(L)-DOPA methyl ester (H-Mdp-OMe) with Boc anhydride, the formation of N,O-di-Boc derivatives was observed. Selective aminolysis of the catechol tert-butyl carbonate group was achieved using pyrrolidine as nucleophile. Treatment of the resulting Boc-Mdp-OMe by Cs2CO3 in MeOH, followed by bis-O-alkylation with cyclization using various polyethyleneglycol ditosylates or catechol-derived bis-polyethyleneglycol ditosylates in DMF at 60°C, led to the derivatives Boc-[15-C-5]-Mdp-OMe, Boc-[18-C-6]-Mdp-OMe, Boc-[benzo-18-C-6]-Mdp-OMe, Boc-[benzo-24-C-8]-Mdp-OMe and then after saponification, to the corresponding Nα-protected amino acids. The tripeptides Fmoc-Ala-[18-C-6]-Mdp-Ala-OMe and Boc-Aib-[18-C-6]-Mdp-Ala-OMe were prepared in solution by using Ala and Aib UNCAs for coupling at the N terminus of the [18-C-6]-Mdp residue and the EDC/HOAt method for coupling Ala at its C terminus.

Neutral Ligands with Surfactant-Type Structure - Synthesis, Complexation, and Ion Transfer

New lipophilic neutral ligands which combine crown ether and podand characteristics with structural features of surfactants (cf. formulas 1-12, 16-26) were synthesized.Their complexation behaviour was studied, their solid-to-liquid and liquid-to-liquid phase transfer properties as well as their efficiency in ion transport across a liquid model membrane.Crystalline stoichiometric complexes of the cycles 2a-4a and of 3e with NaSCN, Ba(SCN)2, and BaI2 can be isolated.Among the noncyclic representatives a crystalline complex is obtained only from 11 with BaI2.The ligand 8d behaves in aqueous solution as a typical surfactant showing micelle formation and cloud point.