41029-80-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-phenylthiazol-4-yl)ethanol is used as a pharmaceutical compound for its potential applications in the development of new antimicrobial agents due to its antibacterial and antifungal properties.
Used in Antioxidant Applications:
1-(2-phenylthiazol-4-yl)ethanol is used as an antioxidant agent for its potential role in the development of new drugs for various medical conditions, given its antioxidant activity.
Used in Cancer Treatment:
1-(2-phenylthiazol-4-yl)ethanol is used as a potential therapeutic agent for its investigation in the treatment of cancer, as it has shown promise in this area.
Used in Neurodegenerative Disease Treatment:
1-(2-phenylthiazol-4-yl)ethanol is used as a potential therapeutic agent for its investigation in the treatment of neurodegenerative diseases, as it has shown promise in this area as well.

Upstream product

• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 1001669-22-2 2-phenylthiazole-4-carboxylic acid N-(methoxy)methylamide 
• 10045-52-0 4-Acetyl-2-phenylthiazole 
• 59937-01-8 2-phenylthiazole-4-carboxylic acid ethyl ester 
• 917-64-6 methyl magnesium iodide 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 
• 74-88-4 methyl iodide 
• 4771-31-7 2-phenyl-4-chloromethylthiazole 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 41029-81-6 4-(1-chloro-ethyl)-2-phenyl-thiazole 
• 395070-20-9 1-(2-phenylthiazol-4-yl)ethanamine 
• 1637585-04-6 N-(1-(2-phenylthiazol-4-yl)ethyl)butyramide 
• 1637585-00-2 C₁₁H₁₀N₄S 
• 1637585-20-6 1-(2-phenylthiazol-4-yl)ethanamine 
• 1637585-16-0 1-(2-phenylthiazol-4-yl)ethanamine 
• 1637585-12-6 N-(1-(2-phenylthiazol-4-yl)ethyl)butyramide 
• 1637585-08-0 N-(1-(2-phenylthiazol-4-yl)ethyl)butyramide 
• 1637585-24-0 C₁₁H₁₀N₄S 

Relevant academic research and scientific papers

Tailored sol-gel immobilized lipase preparates for the enzymatic kinetic resolution of heteroaromatic alcohols in batch and continuous flow systems

Tailored immobilized lipases from Candida antarctica B and Pseudomonas fluorescens, with improved thermal and operational stability, were prepared through fine tuning of the structure of the sol-gel matrix, using various binary or ternary precursor mixtures for the EKR of various chiral heteroaromatic secondary alcohols with benzofuran, benzo[b]thiophen, phenothiazine and 2-phenylthiazol moieties. The operational stability in batch process was studied for five selected systems by performing reuse experiments, using the conversion, enantiomeric excesses and enantiomeric ratio as parameters, demonstrating the dependence of the sol-gel lipase preparate performance on the structure of both biocatalyst and substrate. The resolution of the benzofuranic substrates with the best performing biocatalysts was studied in continuous-flow mode, using the productivity as a criterion. The specific reaction rates under continuous-flow operation (rflow) were higher than those obtained in batch mode (rbatch) in both cases, sustaining its usefulness for further process development.

Candida antarctica lipases acting as versatile catalysts for the synthesis of enantiopure (R)- and (S)-1-(2-phenylthiazol-4-yl)ethanamines This paper is dedicated to the anniversary of 95th birthday of Professor Valer Fǎrcǎ?anu.

The synthesis of both enantiomers of four new phenylthiazole-based amines by enantiomer-selective acylation of racemic amines and by hydrolysis of the corresponding racemic amides using lipase B from Candida antarctica (Novozyme 435) as chiral catalyst was performed with good yields and excellent enantioselectivities. In order to prevent the frequently occurring partial racemization of enantiopure amides during chemical hydrolysis to the corresponding (R)-amines, the deprotection of the N-acylated (R)-enantiomers by mild enzymatic hydrolysis with lipase A from C. antarctica immobilized on Celite was also developed.

Heterocycles 32. Efficient kinetic resolution of 1-(2-arylthiazol-4-yl) ethanols and their acetates using lipase B from Candida antarctica

In this paper we describe the chemoenzymatic synthesis of new enantiomerically enriched (R)- and (S)-1-(2-arylthiazol-4-yl)ethanols and their acetates by enzymatic enantioselective acetylation of the racemic alcohols rac-2a-d and by methanolysis of the corresponding racemic esters rac-3a-d mediated by lipase B from Candida antarctica (CaL-B) in non-aqueous media. In terms of stereoselectivity and activity, both procedures, acylation and alcoholysis, gave similar good results (50% conversion, E 〉 200). The absolute configuration of the kinetic resolution products was determined by a detailed 1H NMR study of the Mosher's derivatives of (S)-2b.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.