10045-52-0

Basic information

• Product Name: 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE
• Synonyms: BUTTPARK 153\57-18;1-(2-PHENYL-1,3-THIAZOL-4-YL)-1-ETHANONE;1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE;4-ACETYL-2-PHENYLTHIAZOLE;1-(2-phenylthiazol-4-yl)ethanone;Ethanone, 1-(2-phenyl-4-thiazolyl)-;1-(2-Phenyl-1,3-thiazol-4-yl)ethanone;4-Acetyl-2-phenyl-1,3-thiazole, (4-Acetyl-1,3-thiazol-2-yl)benzene
• CAS NO: 10045-52-0
• Molecular Formula: C₁₁H₉NOS
• Molecular Weight: 203.26
• Mol File: 10045-52-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 353.5 °C at 760 mmHg
• Flash Point: 167.6 °C
• Appearance: /
• Density: 1.203 g/cm³
• Vapor Pressure: 3.58E-05mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• PKA: -0.10±0.10(Predicted)
• CAS DataBase Reference: 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE(10045-52-0)
• EPA Substance Registry System: 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE(10045-52-0)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 10045-52-0(Hazardous Substances Data)

Usage

General Description

1-(2-phenyl-1,3-thiazol-4-yl)ethan-1-one is a chemical compound with a molecular formula C11H9NOS. It is a ketone derivative with a thiazole ring and a phenyl group, and it is commonly used in organic synthesis and pharmaceutical research. 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE is used as a building block in the creation of various pharmaceuticals, agrochemicals, and other specialty chemicals. It has potential applications in the development of new drugs due to its ability to interact with biological systems and its unique chemical properties. Additionally, this compound may also have uses in the development of new materials and in the field of chemical research.

InChI:InChI=1/C11H9NOS/c1-8(13)10-7-14-11(12-10)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 55-21-0 benzamide 
• 5308-51-0 1-bromobutane-2,3-dione 
• 2227-79-4 benzenecarbothioamide 
• 36094-04-9 2-phenyl-1,3-thiazole-4-carboxylic acid chloride 
• 59937-01-8 2-phenylthiazole-4-carboxylic acid ethyl ester 
• 1001669-22-2 2-phenylthiazole-4-carboxylic acid N-(methoxy)methylamide 
• 75-16-1 methylmagnesium bromide 
• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 68158-17-8 1-(2-Phenyl-thiazol-4-yl)-ethanone oxime; hydrobromide 
• 57372-14-2 1-(2-phenylthiazol-4-yl)ethanone oxime 
• 186581-53-3 diazomethane 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 

Downstream Products

• 109991-18-6 (2-phenyl-4-thiazolyl)glyoxal 
• 41029-80-5 rac-1-(2-phenylthiazol-4-yl)ethanol 
• 92575-28-5 1-[2-(3-nitro-phenyl)-thiazol-4-yl]-ethanone 
• 91182-51-3 2-bromo-1-(2-phenyl-thiazol-4-yl)-ethanone 
• 57372-14-2 1-(2-phenylthiazol-4-yl)ethanone oxime 
• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 317827-48-8 2-[1-(2-Phenylthiazol-4-yl)ethylamino]-4-[benzimidazol-1-yl]pyrimidine 
• 94209-74-2 1-(2-phenyl-thiazol-4-yl)-ethanone O-(toluene-4-sulfonyl)-oxime 
• 92695-63-1 2'-(3-nitro-phenyl)-[4,4']bithiazolyl-2-ylamine 

Relevant articles and documents

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Hetarylquinoxalines as thiabendazoleanalogs. Part 4: Synthesis of 2-thiazolyl-quinoxalines

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