10045-52-0

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE is used as a key intermediate in the synthesis of new pharmaceuticals for various therapeutic areas. Its unique chemical structure allows it to interact with biological systems, making it a promising candidate for the development of innovative drugs with novel mechanisms of action.
Used in Agrochemical Development:
In the agrochemical industry, 1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE is utilized as a building block for the creation of new agrochemicals. Its chemical properties enable it to be incorporated into compounds with potential applications in crop protection, pest control, and other agricultural areas.
Used in Specialty Chemicals Production:
1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE is employed as a precursor in the production of specialty chemicals, which are used in a variety of industries, including cosmetics, fragrances, and dyes. Its unique structure and reactivity contribute to the development of high-value specialty products with specific properties.
Used in Material Science Research:
1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE also has potential applications in the field of material science, where it may be used in the development of new materials with unique properties. Its ability to interact with other molecules and its structural features make it a valuable component in the design and synthesis of advanced materials for various applications.
Used in Chemical Research:
1-(2-PHENYL-1,3-THIAZOL-4-YL)ETHAN-1-ONE is a valuable tool in chemical research, where it is used to study reaction mechanisms, explore new synthetic routes, and develop novel chemical methodologies. Its reactivity and structural features make it an interesting subject for fundamental research in organic chemistry.

InChI:InChI=1/C11H9NOS/c1-8(13)10-7-14-11(12-10)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 68158-17-8 1-(2-Phenyl-thiazol-4-yl)-ethanone oxime; hydrobromide 
• 2227-79-4 benzenecarbothioamide 
• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 1001669-22-2 2-phenylthiazole-4-carboxylic acid N-(methoxy)methylamide 
• 75-16-1 methylmagnesium bromide 
• 59937-01-8 2-phenylthiazole-4-carboxylic acid ethyl ester 
• 36094-04-9 2-phenyl-1,3-thiazole-4-carboxylic acid chloride 
• 55-21-0 benzamide 
• 5308-51-0 1-bromobutane-2,3-dione 
• 57372-14-2 1-(2-phenylthiazol-4-yl)ethanone oxime 
• 186581-53-3 diazomethane 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 

Downstream Products

• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 57372-14-2 1-(2-phenylthiazol-4-yl)ethanone oxime 
• 91182-51-3 2-bromo-1-(2-phenyl-thiazol-4-yl)-ethanone 
• 92575-28-5 1-[2-(3-nitro-phenyl)-thiazol-4-yl]-ethanone 
• 109991-18-6 (2-phenyl-4-thiazolyl)glyoxal 
• 21160-68-9 C₁₂H₁₂N₄OS 
• 79424-36-5 2-(2-Phenyl-thiazol-4-yl)-quinoxaline 
• 107263-90-1 (2-Phenyl-4-thiazolyl)acetylene 
• 107263-87-6 4-(2-Phenyl-thiazol-4-yl)-[1,2,3]selenadiazole 
• 107263-94-5 5-(2-Phenyl-4-thiazolyl)-2-thioxo-1,3-thiaselenole 
• 93002-28-9 2-bromo-1-[2-(3-nitro-phenyl)-thiazol-4-yl]-ethanone 
• 92695-63-1 2'-(3-nitro-phenyl)-[4,4']bithiazolyl-2-ylamine 
• 94209-74-2 1-(2-phenyl-thiazol-4-yl)-ethanone O-(toluene-4-sulfonyl)-oxime 
• 317827-48-8 2-[1-(2-Phenylthiazol-4-yl)ethylamino]-4-[benzimidazol-1-yl]pyrimidine 

Relevant academic research and scientific papers

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.

Rh(III)-catalyzed cyclization reaction of azoles with alkynes: Efficient synthesis of azole-fused-pyridines

A Rh(III)-catalyzed cyclization of azoles with alkynes has been developed. A variety of azole-fused-pyridines were obtained in good to excellent yields and regioselectivity. Both the C5 and the C4 position of azoles were suitable for the reaction.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Selenium Heterocycles. XXXVII. Synthesis of 4-(Thiazol-4-yl)-1,2,3-selenadiazoles and 4-(Selenazol-4-yl)-1,2,3-selenadiazoles

Starting from readily available 2-substituted-4-formylthiazoles and selenazoles, a series of 4-(2-aryl-4-selenazolyl)-1,2,3-selenadiazoles I and 4-(2-substituted-4-thiazolyl)-1,2,3-selenadiazoles II were prepared.Pyrolysis of compound II afforded (2-substituted-4-thiazolyl) acetylenes VII.Addition of potassium hydroxide pellets to an alcoholic solution of II gave 2-substituted-1,4-diselenafulvenes VIII.Decomposition of compound II with base followed by the addition of carbon disulfide gave 5-substituted 2-thioxo-1,3-thiaselenoles XI.