3044-06-2

Basic information

• Product Name: (1-Ethoxyethylidene)propanedioic acid diethyl ester
• Synonyms: (1-Ethoxyethylidene)propanedioic acid diethyl ester;Einecs 221-249-3;Malonic acid, (1-ethoxyethylidene)-, diethyl ester;Nsc 233875;Propanedioic acid, (1-ethoxyethylidene)-, diethyl ester;Propanedioic acid, 2-(1-ethoxyethylidene)-, 1,3-diethyl ester;diethyl 2-(1-ethoxyethylidene)Malonate
• CAS NO: 3044-06-2
• Molecular Formula: C₁₁H₁₈O₅
• Molecular Weight: 230.26
• EINECS: 221-249-3
• Mol File: 3044-06-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 26-27℃
• Boiling Point: 123-128℃ (3 Torr)
• Flash Point: 117.3°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.00367mmHg at 25°C
• Refractive Index: 1.4634 (589.3 nm 25℃)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1-Ethoxyethylidene)propanedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Ethoxyethylidene)propanedioic acid diethyl ester(3044-06-2)
• EPA Substance Registry System: (1-Ethoxyethylidene)propanedioic acid diethyl ester(3044-06-2)

Safety Data

• Hazardous Substances Data: 3044-06-2(Hazardous Substances Data)

Usage

General Description

(1-Ethoxyethylidene)propanedioic acid diethyl ester is a chemical compound with the molecular formula C11H18O6. It is commonly used in organic synthesis and as a solvent for various applications. This ester is a colorless to pale yellow liquid with a fruity odor, and it is soluble in water as well as in most organic solvents. It is often used as a precursor in the production of pharmaceuticals, fragrances, and other specialty chemicals. However, it is important to handle this compound with care, as it may be harmful if inhaled, ingested, or in contact with skin.

InChI:InChI=1/C11H18O5/c1-5-14-8(4)9(10(12)15-6-2)11(13)16-7-3/h5-7H2,1-4H3

Upstream product

• 854838-42-9 (1-ethoxy-vinyl)-malonic acid diethyl ester 
• 141-52-6 sodium ethanolate 
• 108-24-7 acetic anhydride 
• 78-39-7 Triethyl orthoacetate 
• 105-53-3 diethyl malonate 
• 74-96-4 ethyl bromide 
• 75-36-5 acetyl chloride 
• 570-08-1 diethyl acetylmalonate 
• 64-67-5 diethyl sulfate 
• 2678-54-8 ketene diethyl acetal 

Downstream Products

• 1374869-11-0 diethyl 2-(1-(3-bromophenylamino)ethylidene)malonate 
• 1228657-25-7 diethyl 2-(1-(5-methylisoxazol-3-ylamino)ethylidene)malonate 
• 41095-07-2 4-chloro-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 66941-63-7 5-(1-ethoxy-vinyl)-5-allyl-barbituric acid 
• 66941-28-4 5-(1-ethoxy-vinyl)-5-ethyl-barbituric acid 
• 66941-21-7 5-(1-ethoxy-ethyl)-5-ethyl-barbituric acid 
• 87948-87-6 5-methyl-1-(2-pyridyl)-7-oxo-1H,7H-pyrazolo<1,5-a>pyrimidine-6-N-(2-pyridyl)carboxamide 
• 50593-70-9 4-chloro-2-methylquinoline-3-carboxylic acid ethyl ester 
• 73987-39-0 ethyl 2-methyl-4-hydroxy-3-quinoline-carboxylate 
• 923585-62-0 2-methyl-4-[4-(3,3,4-trimethylpiperazin-1-yl)phenylamino]quinoline-3-carboxylic acid ethyl ester 
• 737777-86-5 4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]-2-methylquinoline-3-carboxylic acid ethyl ester 
• 81022-80-2 diethyl 2-(1-(phenylamino)ethylidene)malonate 

Relevant articles and documents

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

CHEMICAL COMPOUNDS

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R, R1, R2, R3 and R4 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.