41104-55-6Relevant academic research and scientific papers
Synthesis and biological evaluations of sulfa derivatives bearing heterocyclic moieties.
Abdel-Monem, Wafaa R
, p. 239 - 247 (2007/10/03)
Some new sulfa derivatives bearing a heterocyclic moieties fural, pyrimidinone, thiazolidinone, benzimidazole and 1,2,4-triazinone and the related compounds 2-19 have been synthesized from treatment of sulfa drugs with thioisocyanate, acid chlorides, 3-chloro-1,2,4-triazines, aldehydes, esters and/or 2-methylbenzoxazole followed by ring closure reactions. Structures of the products have been deduced from their elemental analysis and spectral data. Significant antimicrobial activities were observed in vitro for some members of the series. Compounds 9b, 16 are highly active, while compounds 4b, 6d, 7,9a, 10 and 14 showing a moderate active towards gramme positive bacterium (b.subtilis). gramme negative bacterium (E. coli) and two fungi namely (A.nidulans & A.terreus).
Antidiabetic activity of some 1-substituted 3,5-dimethylpyrazoles
Soliman,Darwish
, p. 1659 - 1663 (2007/10/02)
Several new 1-substituted 3,5-dimethylpyrazoles were prepared for testing as hypoglycemic agents. A number of these containing para-substituted 1-carbonylphenylurea and para-substituted 1-carbamoylbenzenesulfonylurea derivatives were found to possess potent hypoglycemic activity.
The Preparation of Sodium 4-Amino-3-nitrobenzenesulfonate and Some Related Compounds
Rosevear, Judi,Wilshire, John F. K.
, p. 1727 - 1732 (2007/10/02)
The sodium salt of 4-amino-3-nitrobenzenesulfonic acid (o-nitroaniline-p-sulfonic acid) has been prepared by the action of dilute sodium hydroxide solution on ethyl carbamate.Central to this synthesis is the finding that the N-ethoxycarbonyl group, when located ortho to a nitro group (but not to a bromo group), is readily removed by dilute sodium hydroxide solution.
