41106-92-7Relevant academic research and scientific papers
Facile synthesis of tumor-associated carbohydrate antigen ganglioside GM3 from sialic acid, lactose, and serine
Xing, Guo-Wen,Chen, Li,Liang, Fen-Fen
experimental part, p. 5963 - 5970 (2010/03/03)
Ganglioside GM3 [α-Neu5Ac-(2,3)-β-Gal-(1,4)-β- Glc-(1,1)Cer; 1] is considered as an important: tumor-associated carbohydrate antigen, which, can be used in the development of tumor vaccine, In this study, a facile and convergent synthetic strat
Practical syntheses of [13C]- and [14C]-labelled glucosphingolipids
Duffin, Gordon R.,Ellames, George J.,Hartmann, Sascha,Herbert, John M.,Smith, David I.
, p. 2237 - 2242 (2007/10/03)
Synthetic routes to [glucose-U-14C]-1-O-(β-D-glucopyranosyl)-N-stearoyl-D-erythro-sp hingosine 1b and to [glucose-13C6]-1-O-(β-D-glucopyranosyl)sphingosine ([glucose-13C6]glucopsychosine, 2b) are described. Whereas the protected ceramide precursor for lb was prepared using conventional methodology, two new strategies were developed in the course of the synthesis of 2b. Of these, one relies on keeping a protecting group in place at all times to avoid the handling difficulties associated with sphingosine 4, while the other generates a protected derivative (24) of sphingosine indirectly by means of a Mitsunobu inversion.
