638-08-4Relevant academic research and scientific papers
Preparation method of distearoyl phosphatidylethanolamine
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Paragraph 0070; 0088-0093, (2021/03/30)
The invention provides a preparation method of distearoyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) under alkaline conditions, carrying out amino protection reaction on glyceryl phosphatidylethanolamine represented by a formula (II) and a compound containing an amino protection group to obtain an intermediate a represented by a formula (III); (2) under the action of a catalyst, carrying out acylation reaction on the intermediate a and stearic anhydride to obtain an intermediate b represented by a formula (IV); and (3) under an acidic condition,carrying out an amino protection group removal reaction on the intermediate b to obtain distearoyl phosphatidylethanolamine represented by a formula (V), wherein R in the formula (III), the formula (IV) and the formula (V) represents an amino protection group. The preparation method is simple to operate, high in product yield and easy for industrial production.
METHOD FOR SEPARATING HIGH-BOILING CARBOXYLIC ACID VINYL ESTER/CARBOXYLIC ACID MIXTURES
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Paragraph 0035-0037, (2017/05/15)
The invention relates to a method for separating a mixture containing at least one carboxylic acid vinyl ester of general formula R′—C(O)O—CH═CH2 and at least one carboxylic acid of general formula R′—COOH, wherein R′ in either case can be an aliphatic group having 12 to 22 C atoms or a cycloaliphatic group having 12 to 22 C atoms, or an aromatic group having 12 to 22 C atoms, and R′ can be identical or different, characterized in that the carboxylic acid is converted to its anhydride R′—C(O)—O—C(O)—R′ and the carboxylic acid vinyl ester is subsequently separated.
Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent
Rouhi-Saadabad, Hamed,Akhlaghinia, Batool
, p. 479 - 485 (2015/01/30)
An efficient mixed reagent for direct synthesis of symmetrical carboxylic anhydrides from carboxylic acids has been prepared. Carboxylic acids are converted to anhydrides using triphenylphosphine/ trichloroisocyanuric acid under mild reaction conditions at room temperature. Short reaction time, excellent yields of products, low cost, availability of reagents, simple experimental procedure, and easy work-up of the products are the main advantages of the presented method.
Light-enabled synthesis of anhydrides and amides
Mccallum, Terry,Barriault, Louis
, p. 2874 - 2878 (2015/03/30)
Recently, we have demonstrated that the photogeneration of Vilsmeier-Haack reagents is possible using only dimethylformamide (DMF) and tetrabromomethane (CBr4) in the bromination of alcohols. Extending these findings to carboxylic acid substrates has produced a mild and facile approach to the in situ formation of symmetric anhydrides, which were conveniently converted to amide derivatives in a one-pot process. The efficient protocols discussed herein are marked by use of UVA LEDs (365 nm), which have reduced the reaction times and come with a low setup cost.
Use of glycerol carbonate in an efficient, one-pot and solvent free synthesis of 1,3-sn-diglycerides
Kargar, Mojgan,Hekmatshoar, Rahim,Ghandi, Mehdi,Mostashari, Abdoljalil
, p. 259 - 264 (2013/07/27)
An efficient solvent-free synthesis of a variety of highly pure 1,3-sn-diglycerides (1,3-sn-diacylglycerols) in a two-step one pot process is described. Heating glycerol carbonate (4-hydroxymethyl-1,3-dioxolan-2-one) with fatty acid anhydrides 2a-d affords 1:1 mixtures of glycerol carbonate fatty esters 3a-3d and the corresponding fatty acids. Further heating the reaction mixtures in the presence of catalytic amounts of 1,4-diazabicyclo[2.2.2]octane (DABCO) at 195-200 °C yields highly pure 1,3-sn-diglycerides 4a-4d.
Iron-catalyzed decarbonylation reaction of aliphatic carboxylic acids leading to α-olefins
Maetani, Shinji,Fukuyama, Takahide,Suzuki, Nobuyoshi,Ishihara, Daisuke,Ryu, Ilhyong
body text, p. 2552 - 2554 (2012/03/26)
The catalytic decarbonylation reaction of aliphatic carboxylic acids can be carried out in the presence of an iron complex, and it proceeds smoothly to give α-olefins with high selectivity. The Royal Society of Chemistry 2012.
PROCESS FOR PRODUCTION OF OLEFIN
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Page/Page column 21, (2011/06/23)
The present invention provides a process for producing an olefin from a carboxylic acid having a β-hydrogen atom or a derivative thereof using the compound containing iodine and at least one metal elements selected from the group consisting of Groups 6, 7, 8, 9, 10 and 11 metals as a catalyst.
Simple preparation of symmetrical carboxylic acid anhydrides by means of Na2CO3/SOCl2
Kazemi,Kiasat,Mombaini
, p. 3219 - 3223 (2008/02/12)
A convenient and general method for the synthesis of symmetrical carboxylic acid anhydrides using sodium carbonate/thionyl chloride is described. Copyright Taylor & Francis Group, LLC.
Mild and efficient synthesis of carboxylic acid anhydrides from carboxylic acids and triazine coupling reagents
Kaminski, Zbigniew J.,Kolesinska, Beata,Malgorzata, Marcinkowska
, p. 3349 - 3358 (2007/10/03)
Anhydrides of carboxylic acids were obtained in 53%-95% yield by treatment of appropriate carboxylic acids with 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) or 2,4-dichloro-6-methoxy-1,3,5-triazine (DCMT) in the presence of N-methylmorpholine. It has been proved that synthesis proceeds via triazine active esters 3a,b, which are able to acylate carboxylate anion but not less nucleophilic carboxylic acid.
Dabco/SOCl2, mild, and convenient reagent for the preparation of symmetrical carboxylic acid anhydrides
Kazemi, Foad,Kiasat, Ali Reza
, p. 2287 - 2291 (2007/10/03)
Various types of carboxylic acids undergo rapid dehydration with 1,4-diazabicyclo[2.2.2]octane, dabco / thionyl chloride, under mild reaction conditions to afford symmetrical acid anhydrides in high isolated yields.
