41109-95-9Relevant articles and documents
Solvent-Free Synthesis of Ethyl α-Cyanocinnamates Catalyzed by K 2O-Al2O3 Using Grinding Method
Wang, Shu-Xiang,Li, Ji-Tai,Yang, Wen-Zhi,Yin, Ya-Hui,Xie, Zi-Hui
, p. 829 - 834 (2004)
K2O-Al2O3 catalyzes the Knoevenagel condensation of ethyl cyanoacetate with aromatic aldehydes, giving ethyl α-cyanocinnamates in 94-98% yield under solvent-free condition by grinding at room temperature.
The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
Jain, Kavita,Chaudhuri, Saikat,Pal, Kuntal,Das, Kalpataru
supporting information, p. 1299 - 1304 (2019/01/21)
The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields (up to 90%). In the presence of a catalytic amount of quinine (15 mol%), the reaction proceeded at room temperature (RT) under solvent-free conditions. In this green approach, the organocatalyst was recovered and recycled for up to four cycles without appreciable loss of activity.
A simple, efficient and green procedure for Knoevenagel condensation in water or under solvent-free conditions
Yu, Ya-Qin,Wang, Zhong-Liang
, p. 288 - 292 (2013/07/27)
1,4-Diazabicyclo[2.2.2]octane was used as an efficient catalyst in the Knoevenagel condensation reaction of various kinds of aromatic/aliphatic/ heterocyclic/α,β-unsaturated aldehydes and ketones with active methylene compounds. This is a convenient and rapid method for Knoevenagel condensation, which affords the corresponding substituted electrophilic alkenes in excellent yields. The reaction condition is mild and the method is operationally simple. The products, only E-isomers were detected, did not need to be purified. The use of water as the reaction mediummakes the process environmentally benign. The catalysts can be recycled six times without activity loss.
