411240-48-7

Basic information

• Product Name: α-phenyl-N-(2-aminofluorenyl)nitrone
• Synonyms: α-phenyl-N-(2-aminofluorenyl)nitrone
• CAS NO: 411240-48-7
• Molecular Weight: 285.345
• Mol File: 411240-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-phenyl-N-(2-aminofluorenyl)nitrone(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-N-(2-aminofluorenyl)nitrone(411240-48-7)
• EPA Substance Registry System: α-phenyl-N-(2-aminofluorenyl)nitrone(411240-48-7)

Safety Data

• Hazardous Substances Data: 411240-48-7(Hazardous Substances Data)

Upstream product

• 607-57-8 2-nitro-9H-fluorene 
• 53-94-1 N-(9H-fluoren-2-yl)hydroxylamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 411240-49-8 N-(benzoyl)-N-(deoxyguanosin-8-yl)-2-aminofluorene 
• 73051-69-1 2-fluoren 
• 29968-75-0 N-acetoxy-N-benzoyl-2-fluorenylamine 

Relevant articles and documents

Synthesis of N-acetoxy-N-benzoyl-2-aminofluorene, an ultimate carcinogen by LTA oxidation of α-phenyl-N-(2-aminofluorenyl)nitrone, and N-(2′-deoxyguanosin-8-yl)-2-aminofluorene

The rearrangement of a new α-phenyl-N-(2-aminofluorenyl)nitrone (8) to a new ultimate carcinogen, N-acetoxy-N-benzoyl-2-aminofluorene (9) is achieved in a lead tetraacetate (LTA) oxidation reaction. Compound 9 reacts with deoxyguanosine (dG) at pH 7.0 to give N-(benzoyl)-N-(deoxyguanosin-8-yl)-2-aminofluorene (10). Subsequent debenzoylation with the heterogeneous system (sodium carbonate/methanol) leads to the C8-adduct, N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (11).