73051-69-1

Basic information

• Product Name: 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE
• Synonyms: 8-(9H-Fluorene-2-ylamino)-2'-deoxyguanosine;8-[(9H-Fluoren-2-yl)amino]-2'-deoxyguanosine;9-(2-Deoxy-β-D-ribofuranosyl)-6,9-dihydro-6-oxo-8-(9H-fluoren-2-ylamino)-3H-purin-2-amine;dG-C8-AF;G-C8-AF;Aminofluorene-dg;Dg-8-af;Guanosine, 2'-deoxy-8-(9H-fluoren-2-ylamino)-
• CAS NO: 73051-69-1
• Molecular Formula: C₂₃H₂₂N₆O₄
• Molecular Weight: 446.46
• Product Categories: Bases & Related Reagents;Nucleotides
• Mol File: 73051-69-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE(73051-69-1)
• EPA Substance Registry System: 2'-DEOXY-8-(9H-FLUOREN-2-YLAMINO)-GUANOSINE(73051-69-1)

Safety Data

• Hazardous Substances Data: 73051-69-1(Hazardous Substances Data)

Usage

Uses

A C8-deoxyguanosine adduct of the dietary mutagen IQ

Definition

ChEBI: Guanosine substituted at the purine 8-position by a (9H-fluoren-2-yl)amino group.

Upstream product

• 607-57-8 2-nitro-9H-fluorene 
• 70-18-8 GLUTATHIONE 
• 153-78-6 2-aminofluorene 
• 1124321-52-3 8N-(2-aminofluorenyl)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 53-95-2 N-Hydroxy-2-acetylaminofluoren 
• 6098-44-8 NA-AAF 
• 37819-60-6 N-(deoxyguanosin-8-yl)-2-acetamidofluorene 
• 29968-75-0 N-acetoxy-N-benzoyl-2-fluorenylamine 
• 411240-48-7 α-phenyl-N-(2-aminofluorenyl)nitrone 
• 53-94-1 N-(9H-fluoren-2-yl)hydroxylamine 
• 479408-36-1 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-3',5'-O-bis(tert-butyldimethylsilyl)-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine 
• 479408-40-7 N-[6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(9H-fluoren-2-ylamino)-9H-purin-2-yl]-2-(4-isopropyl-phenoxy)-acetamide 
• 479408-23-6 O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine 
• 479408-42-9 8-(N-acetyl-2-amino-fluorene)-O⁶-benzyl-N²-(p-isopropylphenoxyacetyl)-2'-deoxyguanosine 

Relevant articles and documents

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes. The Royal Society of Chemistry 2009.

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

Site-specific synthesis and properties of oligonucleotides containing C8-deoxyguanosine adducts of the dietary mutagen IQ

The site-specific synthesis of oligonucleotides containing the C8-deoxyguanosine adduct of the highly mutagenic heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) has been achieved, and the oligonucleotides were characterized by UV melting te