41139-95-1

Usage

General Description

2-[(4-aminophenyl)amino]benzoic acid, also known as 4-Aminosalicylic acid or PAS, is an aromatic amine compound with the chemical formula C13H11N3O3. It is commonly used in the treatment of tuberculosis and as a diagnostic tool for assessing liver function. 4-Aminosalicylic acid works by inhibiting the growth of tuberculosis bacteria in the body, making it an important component of combination therapy for the disease. In addition, it is sometimes used in conjunction with other medications to treat certain types of inflammatory bowel disease, such as ulcerative colitis. 2-[(4-aminophenyl)amino]benzoic acid is typically administered orally in the form of a tablet or capsule and may have potential side effects, including gastrointestinal disturbances and allergic reactions. Overall, 4-Aminosalicylic acid plays a crucial role in the management of tuberculosis and related conditions, making it an important chemical in the field of medicine.

InChI:InChI=1/C13H12N2O2/c14-9-5-7-10(8-6-9)15-12-4-2-1-3-11(12)13(16)17/h1-8,15H,14H2,(H,16,17)

Upstream product

• 7221-31-0 SM⁽⁰¹⁷⁾R₀₀₁₉₀₈ 
• 118-92-3 anthranilic acid 
• 106-40-1 4-bromo-aniline 
• 106-50-3 1,4-phenylenediamine 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 27918-14-5 2-aminoacridone 
• 27163-12-8 2-Carboxy-4'-isothiocyano-diphenylamin 

Relevant academic research and scientific papers

A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site

The design and synthesis of a glucose-based acridone derivative (GLAC), a potent inhibitor of glycogen phosphorylase (GP) are described. GLAC is the first inhibitor of glycogen phosphorylase, the electronic absorption properties of which are clearly distinguishable from those of the enzyme. This allows probing subtle interactions in the catalytic site. The GLAC absorption spectra, associated with X-ray crystallography and quantum chemistry calculations, reveal that part of the catalytic site of GP behaves as a highly basic environment in which GLAC exists as a bis-anion. This is explained by water-bridged hydrogen-bonding interactions with specific catalytic site residues.

Structure-trypanodical activity relationships

A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.

Synthesis of N-phenylanthranilic acids using water as solvent

A study of some parameters which influence the Ullmann-Goldberg condensation for the synthesis of N-phenylanthranilic acids was done, showing that these acids can be obtained efficiently using water as solvent.

Light-sensitive polycondensation product containing diazonium and dialdehyde groups, and light-sensitive recording material prepared therewith

A light-sensitive diazonium group-containing polycondensation product of a diazonium salt corresponding to the general formula STR1 wherein R1, R2, and R3 denote hydrogen atoms, halogen atoms, alkyl groups having 1 to 3 carbon atoms or alkoxy groups having 1 to 6 carbon atoms, and X denotes the anion of the diazonium salt, and an aldehyde selected from the group consisting of dialdehydes, acetals of dialdehyde hydrates, and esters of dialdehyde hydrates, a process for producing such a light-sensitive polycondensation product and a light-sensitive recording material comprising a layer support and a light-sensitive layer containing such a light-sensitive polycondensation product.