41175-07-9Relevant articles and documents
A Convenient Synthesis of Indazoles
Croce, Piero Dalla,Rosa, Concetta La
, p. 982 - 983 (1984)
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Synthetic method of 1,3-diaryl-1,5,6,7-tetrahydro-indazole derivant
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Paragraph 0027; 0028; 0029; 0030; 0051 0053; 0055; 0056, (2018/07/28)
The invention discloses a synthetic method of a 1,3-diaryl-1,5,6,7-tetrahydro-indazole derivant, and relates to the technical field of synthesis of indazole derivants. The synthetic method comprises the following steps: performing reaction on substituted 1,3-cyclohexanedione, substituted beta-nitryl aryl ethylene and substituted phenyl hydrazine by using triethylenediamine as a catalyst in presence of a solvent; performing steaming removal on residual solvents under reduced pressure after reaction is carried out and then adding water so as to obtain an organic phase; sequentially washing the organic phase with water and a saturated saline solution; then performing drying to obtain a crude product; performing column chromatography separation on the crude product to obtain the 1,3-diaryl-1,5,6,7-tetrahydro-indazole derivant. The synthetic method disclosed by the invention is high in yield and has easily-available raw materials; particularly, a substrate hydrazine participates in reactionso as to have highly area selectivity; a product is single, and post-treatment is concise. In addition, according to the method disclosed by the invention, using of a precious metal catalyst and thelike is not needed.
A Convenient synthesis of indazoles
Dalla Croce, Piero,La Rosa, Concetta
, p. 982 - 983 (2017/11/14)
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