41193-24-2

Upstream product

• 75-09-2 dichloromethane 
• 109-89-7 diethylamine 
• 766-97-2 4-n-methylphenylacetylene 
• 50-00-0 formaldehyd 

Downstream Products

• 1239016-75-1 (4-hydroxybut-2-yn-1-yl)[3-(p-tolyl)prop-2-yn-1-yl]diethylammonium chloride 

Relevant academic research and scientific papers

Gram-Scale Synthesis of Cu(II)@COF via Solid-State Coordination Approach for Catalysis of Alkyne-Dihalomethane-Amine Coupling

A novel covalent organic framework material COF-DM, which contains chelating coordination environments, was synthesized at the gram level under mild conditions. In addition, its Cu(II)-loaded complex of Cu(II)@COF-DM was prepared by impregnating COF-DM in

Heterogeneous catalyst Cu@COF-Me-M as well as preparation method and application thereof

The invention particularly relates to a heterogeneous catalyst Cu@COF-Me-M as well as a preparation method and application thereof. An existing heterogeneous catalyst is low in diffusion speed and high in preparation difficulty. The invention provides a heterogeneous catalyst Cu@COF-Me-M, which is prepared by adding a compound shown in a formula I and triformyl phloroglucinol serving as raw materials into a mesitylene, dimethyl sulfoxide and acetic acid reaction system, heating, reacting, and cooling to room temperature to obtain a covalent organic framework COF-Me-M, and reacting with copper chloride to obtain the Cu@COF-Me-M. the heterogeneous catalyst can effectively catalyze a three-component coupling reaction. The heterogeneous catalyst is simpler in preparation process, low in dosage, high in catalytic efficiency and convenient to recover, and has important significance in industrial production.

Recyclable Cu/C3N4 composite catalyzed AHA/A3 coupling reactions for the synthesis of propargylamines

The heterogeneous Cu/C3N4 catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CH2Cl2 and amines (AHA) without additional base. Moreover,

Silica nanospheres supported diazafluorene iron complex: An efficient and versatile nanocatalyst for the synthesis of propargylamines from terminal alkynes, dihalomethane and amines

We present the synthesis of an efficient heterogeneous silica nanosphere supported iron catalyst (SiO2@APTES@DAFO-Fe) and its catalytic application in a one pot three-component coupling reaction of terminal alkynes, dihalomethane and secondary

Catalyst-free activation of methylene chloride and alkynes by amines in a three-component coupling reaction to synthesize propargylamines

Propargylamines are synthesized via metal-free activation of the C-halogen bond of dihalomethanes and the C-H bond of terminal alkynes in a three-component coupling without catalyst or additional base and under mild reaction conditions. The dihalomethanes

Nickel-catalyzed three-component coupling reaction of terminal alkynes, dihalomethane and amines to propargylamines

Direct C - H and C - halogen activation is an important and practical task in C - C, C - N bond formation reactions using alkynes. Propargylic amines are synthetically versatile intermediates for the preparation of many nitrogen-containing biologically ac

PROPARGYLAMINE SYNTHESIS USING A COPPER (I) CATALYSED THREE COMPONENT COUPLING REACTION

The present invention relates to a three component coupling reaction. In this reaction a terminal alkyne or a salt thereof, a geminal dihalide and a primary or secondary amine are reacted in the presence of a copper (I) catalyst to produce a propargylamin

Cobalt-catalyzed alkyne-dihalomethane-amine coupling: An efficient route for propargylamines

A cobalt-catalyzed three-component coupling of terminal alkynes, dihalomethanes, and amines was developed. This method offers an efficient way for propargylamines via the dual activation of C-H and C-halogen bond. The reaction uses cheap CoBr2

Copper-catalyzed three-component coupling of terminal alkyne, dihalomethane and amine to propargylic amines

The direct C-H and C-halogen activation for C-C bond formation is one of the most interesting reactions in organic chemistry. C-C bond formation using alkynes as a carbon nucleophilic source is a very useful method in synthesis. Herein, a copper(I) chlori