41193-24-2

Upstream product

• 75-09-2 dichloromethane 
• 109-89-7 diethylamine 
• 766-97-2 4-n-methylphenylacetylene 
• 50-00-0 formaldehyd 

Downstream Products

• 1239016-75-1 (4-hydroxybut-2-yn-1-yl)[3-(p-tolyl)prop-2-yn-1-yl]diethylammonium chloride 

Relevant academic research and scientific papers

Heterogeneous catalyst Cu@COF-Me-M as well as preparation method and application thereof

The invention particularly relates to a heterogeneous catalyst Cu@COF-Me-M as well as a preparation method and application thereof. An existing heterogeneous catalyst is low in diffusion speed and high in preparation difficulty. The invention provides a heterogeneous catalyst Cu@COF-Me-M, which is prepared by adding a compound shown in a formula I and triformyl phloroglucinol serving as raw materials into a mesitylene, dimethyl sulfoxide and acetic acid reaction system, heating, reacting, and cooling to room temperature to obtain a covalent organic framework COF-Me-M, and reacting with copper chloride to obtain the Cu@COF-Me-M. the heterogeneous catalyst can effectively catalyze a three-component coupling reaction. The heterogeneous catalyst is simpler in preparation process, low in dosage, high in catalytic efficiency and convenient to recover, and has important significance in industrial production.

Gram-Scale Synthesis of Cu(II)@COF via Solid-State Coordination Approach for Catalysis of Alkyne-Dihalomethane-Amine Coupling

A novel covalent organic framework material COF-DM, which contains chelating coordination environments, was synthesized at the gram level under mild conditions. In addition, its Cu(II)-loaded complex of Cu(II)@COF-DM was prepared by impregnating COF-DM in

Recyclable Cu/C3N4 composite catalyzed AHA/A3 coupling reactions for the synthesis of propargylamines

The heterogeneous Cu/C3N4 catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CH2Cl2 and amines (AHA) without additional base. Moreover,

Silica nanospheres supported diazafluorene iron complex: An efficient and versatile nanocatalyst for the synthesis of propargylamines from terminal alkynes, dihalomethane and amines

We present the synthesis of an efficient heterogeneous silica nanosphere supported iron catalyst (SiO2@APTES@DAFO-Fe) and its catalytic application in a one pot three-component coupling reaction of terminal alkynes, dihalomethane and secondary

Catalyst-free activation of methylene chloride and alkynes by amines in a three-component coupling reaction to synthesize propargylamines

Propargylamines are synthesized via metal-free activation of the C-halogen bond of dihalomethanes and the C-H bond of terminal alkynes in a three-component coupling without catalyst or additional base and under mild reaction conditions. The dihalomethanes

Nickel-catalyzed three-component coupling reaction of terminal alkynes, dihalomethane and amines to propargylamines

Direct C - H and C - halogen activation is an important and practical task in C - C, C - N bond formation reactions using alkynes. Propargylic amines are synthetically versatile intermediates for the preparation of many nitrogen-containing biologically ac

PROPARGYLAMINE SYNTHESIS USING A COPPER (I) CATALYSED THREE COMPONENT COUPLING REACTION

The present invention relates to a three component coupling reaction. In this reaction a terminal alkyne or a salt thereof, a geminal dihalide and a primary or secondary amine are reacted in the presence of a copper (I) catalyst to produce a propargylamin

Cobalt-catalyzed alkyne-dihalomethane-amine coupling: An efficient route for propargylamines

A cobalt-catalyzed three-component coupling of terminal alkynes, dihalomethanes, and amines was developed. This method offers an efficient way for propargylamines via the dual activation of C-H and C-halogen bond. The reaction uses cheap CoBr2

Copper-catalyzed three-component coupling of terminal alkyne, dihalomethane and amine to propargylic amines

The direct C-H and C-halogen activation for C-C bond formation is one of the most interesting reactions in organic chemistry. C-C bond formation using alkynes as a carbon nucleophilic source is a very useful method in synthesis. Herein, a copper(I) chlori