4120-05-2Relevant articles and documents
Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors
Kayamba, Francis,Malimabe, Teboho,Ademola, Idowu Kehinde,Pooe, Ofentse Jacob,Kushwaha, Narva Deshwar,Mahlalela, Mavela,van Zyl, Robyn L.,Gordon, Michelle,Mudau, Pertunia T.,Zininga, Tawanda,Shonhai, Addmore,Nyamori, Vincent O.,Karpoormath, Rajshekhar
, (2021/03/22)
Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative antimalarial therapies are urgently needed. In line with this
PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
Zhang, Yanzhi,Lei, Min,Xue, Kangsheng,Sun, Guoxiang,Zhou, Yang,Hou, Jinjun,Long, Huali,Zhang, Zijia,Chen, Xubing,Wu, Wanying
, p. 3661 - 3668 (2020/09/11)
A method using PPh3/I2-catalyzed three-component Biginelli reaction of aromatic ketone, aromatic aldehyde and urea to synthesize4,6-diarylpyrimidin-2-(1H)-ones is described. Under the experimental conditions, the main reaction produc
Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions
Beerappa, Mallappa,Shivashankar, Kalegowda
, p. 2150 - 2158 (2018/07/21)
A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step.
Highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones using N,N,N′,N′-Tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate as a dual-functional catalyst
Khanivar, Roghayyeh,Zare, Abdolkarim
, p. 635 - 640 (2018/08/07)
The highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones via the one-pot multicomponent reaction of acetophenones with arylaldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of the ionic liquid N,N,N′,N′-Tetrameth
Photo-dehydrogenation of 4,6-diaryl-2-oxo-1,2,3,4-tetrahydropyrimidines
Memarian, Hamid Reza,Sanchooli, Esmael
, p. 1335 - 1346 (2017/06/06)
Electron-transfer-induced photo-oxidation of 4,6-diaryl-substituted 2-oxo-1,2,3,4-tetrahydropyrimidines (THPMs) in chloroform under argon atmosphere results in the smooth formation of 4,6-diaryl-substituted 2-oxo-1,2-dihydropyrimidines. Sequentially, elec
Method for catalytically synthesizing 4,6-diaryl pyrimidine-2(1H)-one derivative by using sulfonic acid functional chitosan
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Paragraph 0037; 0038; 0058-0062, (2018/01/04)
The invention belongs to the technical field of green organic chemistry, and particularly relates to a method for catalytically synthesizing a pyrimidones derivative by using natural polymer modified sulfonic acid functional chitosan. The method comprises
Capto-Dative Stabilization by Thermal Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines
Memarian, Hamid R.,Sanchooli, Esmael,Rudbari, Hadi Amiri,Bruno, Giuseppe
, p. 872 - 880 (2016/08/10)
Various 4,6-diaryl substituted 2-oxo-1,2,3,4-tetrahydropyrimidines (THPMs) were oxidized to 2-oxo-1,2-dihydropyrimidines (DHPMs) by potassium peroxydisulfate (PPS) in aqueous acetonitrile solution under thermal conditions. Based on the proposed oxidation
Br?nsted acidic ionic liquids catalyzed three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions
Mollashahi, Ebrahim,Biabangard, Asiyeh
, p. 732 - 738 (2016/01/12)
4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component reaction of aromatic aldehyde derivatives, acetophenone, and urea (thiourea) in the presence of Br?nsted acidic ionic liquids such as triethylammonium hydrogensulfate, N-
A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition
Pasha, Mohamed Afzal,Nagashree, Shrivatsa
, p. 1279 - 1283 (2014/04/03)
A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is develop
4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors
Shukla, Shiwani,Kumar, Dinesh,Ojha, Ritu,Gupta, Manish K.,Nepali, Kunal,Bedi, Preet M. S.
, p. 486 - 495 (2014/07/21)
Summary A series of 4,6-diaryl/heteroarylpyrimidones was synthesized employing silica-supported fluoroboric acid under solvent-free conditions in a microwave reactor. The catalytic influence of HBF4-SiO2 was investigated in detail to