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4,6-Diphenylpyrimidin-2-ol is a pyrimidine derivative with the molecular formula C17H13N3O. It features a pyrimidine ring structure adorned with two phenyl groups at the 4th and 6th positions. This chemical compound is recognized for its potential in pharmaceutical and research applications, primarily serving as a building block in the synthesis of biologically active compounds. Its distinctive structural attributes and properties render it a valuable intermediate in the realms of organic synthesis and medicinal chemistry. Additionally, 4,6-Diphenylpyrimidin-2-ol has garnered interest due to its potential pharmacological activities, positioning it as a promising subject for ongoing research and development.

4120-05-2

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4120-05-2 Usage

Uses

Used in Pharmaceutical Industry:
4,6-Diphenylpyrimidin-2-ol is utilized as a key intermediate in the synthesis of various biologically active compounds, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of molecules with specific therapeutic properties, making it an essential component in medicinal chemistry.
Used in Research Applications:
In the scientific community, 4,6-Diphenylpyrimidin-2-ol serves as a valuable research tool. It is employed in the exploration of new chemical reactions and synthetic pathways, furthering understanding in organic synthesis. Additionally, its potential pharmacological activities are under investigation, which could lead to the discovery of novel therapeutic agents.
Used in Organic Synthesis:
4,6-Diphenylpyrimidin-2-ol is applied as a versatile building block in organic synthesis. Its presence in the synthesis of complex organic molecules highlights its utility in creating a diverse range of chemical entities with potential applications across various industries.
Used in Medicinal Chemistry:
As a pyrimidine derivative, 4,6-Diphenylpyrimidin-2-ol is integral to the field of medicinal chemistry. It is used in the design and synthesis of pharmaceutical agents, particularly those targeting specific biological pathways or receptors, underpinning the development of targeted therapies for various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 4120-05-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,2 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4120-05:
(6*4)+(5*1)+(4*2)+(3*0)+(2*0)+(1*5)=42
42 % 10 = 2
So 4120-05-2 is a valid CAS Registry Number.

4120-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-diphenyl-1H-pyrimidin-2-one

1.2 Other means of identification

Product number -
Other names 4,6-diphenylpyrimidin-2-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4120-05-2 SDS

4120-05-2Relevant articles and documents

Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

Kayamba, Francis,Malimabe, Teboho,Ademola, Idowu Kehinde,Pooe, Ofentse Jacob,Kushwaha, Narva Deshwar,Mahlalela, Mavela,van Zyl, Robyn L.,Gordon, Michelle,Mudau, Pertunia T.,Zininga, Tawanda,Shonhai, Addmore,Nyamori, Vincent O.,Karpoormath, Rajshekhar

, (2021/03/22)

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative antimalarial therapies are urgently needed. In line with this

PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones

Zhang, Yanzhi,Lei, Min,Xue, Kangsheng,Sun, Guoxiang,Zhou, Yang,Hou, Jinjun,Long, Huali,Zhang, Zijia,Chen, Xubing,Wu, Wanying

, p. 3661 - 3668 (2020/09/11)

A method using PPh3/I2-catalyzed three-component Biginelli reaction of aromatic ketone, aromatic aldehyde and urea to synthesize4,6-diarylpyrimidin-2-(1H)-ones is described. Under the experimental conditions, the main reaction produc

Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions

Beerappa, Mallappa,Shivashankar, Kalegowda

, p. 2150 - 2158 (2018/07/21)

A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step.

Highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones using N,N,N′,N′-Tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate as a dual-functional catalyst

Khanivar, Roghayyeh,Zare, Abdolkarim

, p. 635 - 640 (2018/08/07)

The highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones via the one-pot multicomponent reaction of acetophenones with arylaldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of the ionic liquid N,N,N′,N′-Tetrameth

Photo-dehydrogenation of 4,6-diaryl-2-oxo-1,2,3,4-tetrahydropyrimidines

Memarian, Hamid Reza,Sanchooli, Esmael

, p. 1335 - 1346 (2017/06/06)

Electron-transfer-induced photo-oxidation of 4,6-diaryl-substituted 2-oxo-1,2,3,4-tetrahydropyrimidines (THPMs) in chloroform under argon atmosphere results in the smooth formation of 4,6-diaryl-substituted 2-oxo-1,2-dihydropyrimidines. Sequentially, elec

Method for catalytically synthesizing 4,6-diaryl pyrimidine-2(1H)-one derivative by using sulfonic acid functional chitosan

-

Paragraph 0037; 0038; 0058-0062, (2018/01/04)

The invention belongs to the technical field of green organic chemistry, and particularly relates to a method for catalytically synthesizing a pyrimidones derivative by using natural polymer modified sulfonic acid functional chitosan. The method comprises

Capto-Dative Stabilization by Thermal Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines

Memarian, Hamid R.,Sanchooli, Esmael,Rudbari, Hadi Amiri,Bruno, Giuseppe

, p. 872 - 880 (2016/08/10)

Various 4,6-diaryl substituted 2-oxo-1,2,3,4-tetrahydropyrimidines (THPMs) were oxidized to 2-oxo-1,2-dihydropyrimidines (DHPMs) by potassium peroxydisulfate (PPS) in aqueous acetonitrile solution under thermal conditions. Based on the proposed oxidation

Br?nsted acidic ionic liquids catalyzed three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions

Mollashahi, Ebrahim,Biabangard, Asiyeh

, p. 732 - 738 (2016/01/12)

4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component reaction of aromatic aldehyde derivatives, acetophenone, and urea (thiourea) in the presence of Br?nsted acidic ionic liquids such as triethylammonium hydrogensulfate, N-

A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

Pasha, Mohamed Afzal,Nagashree, Shrivatsa

, p. 1279 - 1283 (2014/04/03)

A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is develop

4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors

Shukla, Shiwani,Kumar, Dinesh,Ojha, Ritu,Gupta, Manish K.,Nepali, Kunal,Bedi, Preet M. S.

, p. 486 - 495 (2014/07/21)

Summary A series of 4,6-diaryl/heteroarylpyrimidones was synthesized employing silica-supported fluoroboric acid under solvent-free conditions in a microwave reactor. The catalytic influence of HBF4-SiO2 was investigated in detail to

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