412008-06-1Relevant academic research and scientific papers
Synthesis and antitumour activity of new dendritic polyamines-(imide-DNA-intercalator) conjugates: Potent Lck inhibitors
Bra?a, Miguel F.,Domínguez, Gema,Sáez, Beatriz,Romerdahl, Cynthia,Robinson, Simmon,Barlozzari, Teresa
, p. 541 - 551 (2002)
A series of dendritic polyamines-(imide-DNA-intercalators) conjugates with different connectivity in their basic chain were synthesised and evaluated as antitumour compounds. Although their antiproliferative activity against HT-29 was not significant, con
Synthesis of antitumor dendritic imides
Braa, Miguel F.,Dominguez, Gema,Saez, Beatriz,Romerdahl, Cynthia,Robinson, Simmon,Barlozzari, Teresa
, p. 3027 - 3029 (2001)
Dendritic imides were synthesized and evaluated as antitumor compounds. Compounds 8 and 11 showing a promising profile as inhibitors of lck but their antiproliferative activity against HT-29 was not so relevant.
