412008-69-6

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 273749-26-1 4-hydroxymethyl-2-(2-nitrophenyl)-benzimidazole 
• 412008-70-9 N-methyl-4-methyl-2-(2-nitrophenyl)-benzimidazole 
• 626605-88-7 1-[4-methyl-2-(2-nitrophenyl)benzimidazol-1-yl]propan-2-ol 
• 626605-94-5 3,3-dimethyl-1-[4-methyl-2-(2-nitrophenyl)benzimidazol-1-yl]butan-2-ol 
• 626605-98-9 2-methyl-1-[4-methyl-2-(2-nitrophenyl)benzimidazol-1-yl]propan-2-ol 
• 626605-90-1 1-[4-methyl-2-(2-nitrophenyl)benzimidazol-1-yl]hexan-2-ol 

Relevant academic research and scientific papers

Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles

Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and 1H NMR and their α-glucosidase inhibitory activities were found out experimentally. Compound 25, 19, 10 and 20 have best inhibitory activities with IC50 values 5

Water-mediated synthesis of 2-substituted benzimidazoles by boric acid and glycerol

A very simple, mild, and highly efficient green catalyst has been developed for the synthesis of 2-substituted benzimidazoles by treatment of substituted ortho-phenylenediamines and aldehydes in water at 80C in the presence of boric acid (5 mol-%) and glycerol (0.05 mL). This methodology has been standardized on 55 substrates, and nine new compounds have been synthesized.

Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands

A new class of tetracylic benzimidazole compounds and derivatives thereof. Additionally provided is a synthetic route for the generation of these and related compounds via Intramolecular Aromatic Nucleophilic Substitution (SNAr) of the Benzimid

Intramolecular Aromatic Nucleophilic Substitution of the Benzimidazole-Activated Nitro Group

(Equation Presented) A wide range of 2-(2-nitrophenyl)-1H-benzimidazoles undergo high-yielding intramolecular SNAr of nitrite with N-pendant alkoxides under mild conditions (DMF, rt). When this operationally simple process is carried out at ele

Cyclic bis-benzimidazole ligands and metal complexes thereof

Cyclic bis benzimidazole ligands of the following formula are formed by contacting a (2-aminophenyl)-benzimidazole-4-carboxaldehyde ethylene acetal or a (2-nitrophenyl)-benzimidazole-4-benzaldehyde with an acid optionally in the presence of a metal or a metal salt. wherein R1and R2may be the same or different and are selected from H, an alkyl having 1 to 10 carbon atoms, a benzyl group, a substituted 2-ethylphenyl group, a carbonyl group, a phenyl substituent, a tosyl group, and an alkylsulfonate group; R3and R4may be the same or different and are selected from H, methyl, and ethyl; and R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18may be the same or different and are selected from H, alkyl having 1 to 10 carbon atoms, fluoride, chloride, bromide, iodide, nitro, amino, a carboxylate, an ester, and a phenyl group.