412044-48-5

Basic information

• Product Name: Magnesium, bromo(4-cyanophenyl)-
• CAS NO: 412044-48-5
• Molecular Formula: C7H4BrMgN
• Molecular Weight: 206.324
• Mol File: 412044-48-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Magnesium, bromo(4-cyanophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Magnesium, bromo(4-cyanophenyl)-(412044-48-5)
• EPA Substance Registry System: Magnesium, bromo(4-cyanophenyl)-(412044-48-5)

Safety Data

• Hazardous Substances Data: 412044-48-5(Hazardous Substances Data)

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 171364-82-2 4-cyanophenylboronic acid pinacol ester 
• 50670-50-3 p-(p-tolyl)benzonitrile 
• 1503-49-7 p-cyanobenzophenone 
• 55805-10-2 4-cyano-1-difluoromethylbenzene 
• 174813-84-4 4-(hydroxy(4-methoxyphenyl)methyl)benzonitrile 
• 52126-09-7 4-(4-methoxyphenylmethyl)benzonitrile 
• 486455-27-0 3'-hydroxybiphenyl-4-carbonitrile 
• 123732-13-8 4-(3-oxocyclohex-1-enyl)-benzonitrile 
• 10540-31-5 4-cyano-4'-fluorobiphenyl 
• 58743-77-4 4'-methoxybiphenyl-4-carbonitrile 
• 161664-51-3 C₉H₁₀BNO₂ 

Relevant articles and documents

Structural Studies on 4,5-Disubstituted 2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to β-Lactams

A library of 4,5-disubstituted 2-aminoimidazole triazole amide (2-AITA) conjugates has been successfully assembled. Upon biological screening, this class of small molecules was discovered as enhanced biofilm regulators through non-microbicidal mechanisms against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB), with active concentrations in the low micromolar range. The library was also subjected to synergism and resensitization studies with β-lactam antibiotics against MRSA. Lead compounds were identified that suppress the antibiotic resistance of MRSA by working synergistically with oxacillin, a β-lactam antibiotic resistant to penicillinase. A further structure-activity relationship (SAR) study on the parent 2-AITA compound delivered a 2-aminoimidazole diamide (2-AIDA) conjugate with significantly increased synergistic activity with oxacillin against MRSA, decreasing the MIC value of the β-lactam antibiotic by 64-fold. Increased anti-biofilm activity did not necessarily lead to increased suppression of antibiotic resistance, which indicates that biofilm inhibition and resensitization are most likely occurring via distinct mechanisms.

Method of preparing organomagnesium compounds

The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts - LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.