58743-77-4

Basic information

• Product Name: 4'-methoxy[1,1'-biphenyl]-4-carbonitrile
• Synonyms: 4-Methoxy-4'-cyanobiphenyl;4-Methoxy-4'-cyano-1,1'-biphenyl;1OCB;4-(4-Methoxyphenyl)benzonitrile;4-Cyano-4'-methoxybiphenyl;4-Methoxybiphenyl-4'-carbonitrile;4-Methoxy-[1,1'-biphenyl]-4'-carbonitrile;(1,1'-Biphenyl)-4-carbonitrile, 4'-methoxy-
• CAS NO: 58743-77-4
• Molecular Formula: C14H11NO
• Molecular Weight: 209.24
• EINECS: 261-416-8
• Mol File: 58743-77-4.mol
• Article Data: 212

Chemical Properties

• Boiling Point: 368.8 °C at 760 mmHg
• Flash Point: 155.5 °C
• Appearance: /
• Density: 1.14g/cm³
• CAS DataBase Reference: 4'-methoxy[1,1'-biphenyl]-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-methoxy[1,1'-biphenyl]-4-carbonitrile(58743-77-4)
• EPA Substance Registry System: 4'-methoxy[1,1'-biphenyl]-4-carbonitrile(58743-77-4)

Safety Data

• Hazardous Substances Data: 58743-77-4(Hazardous Substances Data)

Usage

General Description

4'-methoxy[1,1'-biphenyl]-4-carbonitrile is a chemical compound that consists of a biphenyl core with a methoxy group substituted at the 4' position and a carbonitrile group at the 4 position. It is a white to off-white crystalline powder that is mainly used as an intermediate in the synthesis of pharmaceutical compounds and organic electronic materials. 4'-methoxy[1,1'-biphenyl]-4-carbonitrile is known to have potential medicinal properties, making it a valuable building block in drug discovery and development. Additionally, it has been studied for its role in organic semiconductor devices due to its unique electronic and physical properties. Overall, 4'-methoxy[1,1'-biphenyl]-4-carbonitrile is a versatile compound with various potential applications in the pharmaceutical and materials science industries.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 130952-94-2 (dichloro)(ethyl)(4-methoxyphenyl)silane 
• 3058-39-7 4-iodobenzonitrile 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 696-62-8 para-iodoanisole 
• 126747-14-6 4-cyanophenylboronic acid 
• 19812-93-2 4-Cyano-4'-hydroxybiphenyl 
• 74-88-4 methyl iodide 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 72352-76-2 4'-methoxy-4-biphenyl carboxamide 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 138373-10-1 4-cyanophenyl mesylate 

Downstream Products

• 613-37-6 4-methoxylbiphenyl 
• 1332363-01-5 4-methoxy-4'-deutero-1,1'-biphenyl 
• 19812-93-2 4-Cyano-4'-hydroxybiphenyl 
• 52364-73-5 4-octyloxy-4'-cyanobiphenyl 
• 59748-18-4 4'-octyloxy(1,1'-biphenyl)-4-carboxylic acid 

Relevant articles and documents

Preparation, structure and catalytic properties of a binuclear Pd(0) complex with bridging silylene ligands

In contrast to the N-heterocyclic carbene (NHC) 1, the homologous N-heterocyclic silylene (NHS) 4 acts as a bridging ligand to Pd(0), giving rise to the dinuclear complex 5 which is catalytically active in Suzuki reactions.

Biaryl Coupling of Aryldiazonium Salts and Arylboronic Acids Catalysed by Gold

A gold-catalysed coupling of aryldiazonium salts with arylboronic acids is described. The reactions proceed in satisfactory yields under irradiation with blue LEDs in the presence of KF and a catalytic amount of ascorbic acid. Notably, 4-nitrobenzendiazonium tetrafluoroborate is sufficiently reactive to undergo the coupling with a variety of arylboronic acids in the absence of aryl radical initiators. The coupling is applicable for electron-donating and electron-withdrawing groups present at the para, ortho, and meta positions of both substrates.

Preparation of Functionalized Diorganomagnesium Reagents in Toluene via Bromine or Iodine/Magnesium-Exchange Reactions

A wide range of polyfunctionalized di(hetero)aryl- and dialkenyl-magnesium reagents are prepared in toluene within 10 to 120 minutes between 78 C and 25 C via an I/Mg- or Br/Mg-exchange reaction using reagents of the general formula R2Mg (R = sBu, Mes). Highly sensitive functional groups, such as triazene or nitro, are tolerated in these exchange reactions, enabling the synthesis of various functionalized (hetero)arene and alkene derivatives after quenching with several electrophiles including allyl bromides, acyl chlorides, aldehydes, ketones, and aryl iodides.