412052-06-3Relevant academic research and scientific papers
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs
Kim, Seongkon,Wu, Jane,Chen, Helen Y.,Birzin, Elizabeth T.,Chan, Wanda,Yang, Yi Tien,Colwell, Lawrence,Li, Susan,Dahllund, Johanna,DiNinno, Frank,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.
, p. 2741 - 2745 (2007/10/03)
A series of estrogen receptor ligands based on a dihydrobenzoxathiin scaffold is described and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. The most active analogue, 22, was found to be 40-fold ERα selective in a comp
Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators
Kim, Seongkon,Wu, Jane Y.,Birzin, Elizabeth T.,Frisch, Katalin,Chan, Wanda,Pai, Lee-Yuh,Yang, Yi Tien,Mosley, Ralph T.,Fitzgerald, Paula M. D.,Sharma, Nandini,Dahllund, Johanna,Thorsell, Ann-Gerd,DiNinno, Frank,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.
, p. 2171 - 2175 (2007/10/03)
The discovery and synthesis of dihydrobenzoxathiins as potent, ERα subtype selective ligands are described. The most active analogue, 4-D, was found to be 50-fold selective in a competitive binding assay and 100-fold selective in a transactivation assay i
ESTROGEN RECEPTOR MODULATORS
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Page/Page column 66, (2010/02/07)
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or preven
Estrogen receptor modulators
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Page 37, (2010/11/29)
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
