688329-73-9Relevant academic research and scientific papers
Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators
Kim, Seongkon,Wu, Jane Y.,Birzin, Elizabeth T.,Frisch, Katalin,Chan, Wanda,Pai, Lee-Yuh,Yang, Yi Tien,Mosley, Ralph T.,Fitzgerald, Paula M. D.,Sharma, Nandini,Dahllund, Johanna,Thorsell, Ann-Gerd,DiNinno, Frank,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.
, p. 2171 - 2175 (2007/10/03)
The discovery and synthesis of dihydrobenzoxathiins as potent, ERα subtype selective ligands are described. The most active analogue, 4-D, was found to be 50-fold selective in a competitive binding assay and 100-fold selective in a transactivation assay i
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs
Kim, Seongkon,Wu, Jane,Chen, Helen Y.,Birzin, Elizabeth T.,Chan, Wanda,Yang, Yi Tien,Colwell, Lawrence,Li, Susan,Dahllund, Johanna,DiNinno, Frank,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.
, p. 2741 - 2745 (2007/10/03)
A series of estrogen receptor ligands based on a dihydrobenzoxathiin scaffold is described and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. The most active analogue, 22, was found to be 40-fold ERα selective in a comp
