412054-27-4Relevant articles and documents
From a biogenetic scenario to a synthesis of the ABC ring of manzamine A
Herdemann, Matthias,Al-Mourabit, Ali,Martin, Marie-Therese,Marazano, Christian
, p. 1890 - 1897 (2002)
On the basis of a biogenetic proposal for explaining the biogenesis of manzamine A, the cycloaddition of dihydropyridinium salt 26 with diene derivative 5 leads to adducts 27. These adducts, as well as their related and previously described analogues 9, are now shown to be precursors of diene derivatives such as 10, 13, and 28. Treatment of diene 32 with sodium azide resulted in a one-step formation of the tricyclic imino derivative 34. This key intermediate was further transformed into tricyclic derivative 40, which possesses the essential features of the ABC ring of manzamine A.
