41212-96-8

Usage

Uses

Used in Oncology:
1-(2-chloroethyl)pyrrolidine-2,5-dione is used as a chemotherapeutic agent for the treatment of certain types of brain tumors, leukemia, lymphoma, and multiple myeloma. It is effective in slowing the progression of these cancers and improving survival rates due to its ability to interfere with the DNA replication process of cancer cells.
Used in Combination Therapy:
1-(2-chloroethyl)pyrrolidine-2,5-dione is used as a component of combination therapy in oncology. When used alongside other chemotherapy drugs, it can enhance the overall effectiveness of cancer treatment and improve patient outcomes.
Used in Healthcare Monitoring:
Due to the potential side effects of 1-(2-chloroethyl)pyrrolidine-2,5-dione, such as bone marrow suppression, increased susceptibility to infections, and kidney damage, it is used as a subject for careful monitoring and management by healthcare professionals. This ensures that the benefits of the drug are maximized while minimizing the risks associated with its use.

InChI:InChI=1/C6H8ClNO2/c7-3-4-8-5(9)1-2-6(8)10/h1-4H2

Upstream product

• 123-56-8 Succinimide 
• 107-07-3 2-chloro-ethanol 
• 107-06-2 1,2-dichloro-ethane 
• 107-04-0 1-Bromo-2-chloroethane 
• 128-09-6 N-chloro-succinimide 
• 74-85-1 ethene 

Relevant academic research and scientific papers

Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants

New twelve in silico designed coumarin-based ERα antagonists, namely 3DQ-1a to 3DQ-1е, were synthesized and confirmed as selective ERα antagonists, showing potencies ranging from single-digit nanomolar to picomolar. The hits were confirmed as selective es

Method for preparing diloxitol fumarate

The invention relates to the technical field of a bulk drug preparation method and in particular relates to a method for preparing a bulk drug diloxitol fumarate. The preparation method comprises thefollowing steps: 1) performing an ammoniation reaction, namely enabling succinic anhydride to react with an ammoniating reagent so as to produce succinimide; 2) performing an alkylation reaction, namely enabling succinimide to react with 1,2 halogenated ethane in the presence of a catalyst and a base so as to generate a compound of a formula IV shown in the description; and 3) performing an esterification reaction, namely enabling a compound of a formula IV compound shown in the description to react with trans-monomethyl fumarate, so as to generate diloxifyl fumarate. The method has the advantages that material reagents used in the method are convenient and easy to obtain, the reaction steps are short, the total yield is high, the product is easy to purify through recrystallization, and base toxic impurities are easy to be controlled through recrystallization, and the like.

A Thiophene Analogue of Praziquantel, and Related Systems, by Intramolecular Cyclisation of Acyliminium Salts

N--succinimide (7a) and -glutarimide (7b) on reduction with sodium borohydride in methanol at -10 deg C yield the respective hydroxylactams which on treatment with formic acid cyclise via the intermediate acyliminium ions to 4,5,9,9a-tetrahydropyrrolothienopyridin-7-one (9a) and 4,5,8,9,10,10a-hexahydropyridothienopyridin-7-one (9b) respectively.In a similar manner, 4-cyclohexylcarbonyl-1-piperazine-2,6-dione (11) is converted into the thiophene isostere (2) of praziquantel (1).Likewise, formic acid induced cyclisations of the hydroxylactams derived from N-- (16) and N-succinimide (19) furnish 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (18) and 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (21), respectively.

Excited-State ? Succimidyl and Glutarimidyl Radicals: Reversible Ring Opening

The free-radical isomerization of N-bromosuccinimide to β-bromopropionyl isocyanate has been examined.Of the two varieties of succinimidyl radical (S? or S?), only the ? excited state undergoes the ring opening to the β propionyl isocyanatyl radical.The conversion optimally takes place in >95percent yield.The dependence of NBS concentration along with results obtained from deuterium labeling studies indicate that the ring opening of S? is a reversible process.This explains the failure of N-chlorosuccinimide to produce β-chloropropionyl isocyanate, as well as the increase in ring-opened product for N-bromosuccinimides upon methyl substitution at the 2- and/or 3-position of the succinimidyl ring, since the open-chain radical intermediates are more stable.In the N-bromoglutarimide system, methyl groups on the 2-position are required for the glutarimidyl radicals to undergo the isomerization, ultimately producing isocyanates.The radical-chain nature of these systems is confirmed.

Acylation of bis(2 chloroethyl)amine (nitrogen mustard)

The preparation is described of N,N bis [2 chloroethyl] amides of fatty and keto acids, of N,N bis [2 chloroethyl] amino acids and of N [2 chloroethyl] imides and amides as potential cytostatic agents.