41212-96-8

Basic information

• Product Name: 1-(2-chloroethyl)pyrrolidine-2,5-dione
• Synonyms: 1-(2-chloroethyl)pyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 1-(2-chloroethyl)-;2-Succinimidoethyl chloride;Einecs 255-266-2;N-(2-Chloroethyl)succinimide;Nsc 58200;1-(2-chloroethyl)pyrrolidine-2,5-dione(SALTDATA: FREE)
• CAS NO: 41212-96-8
• Molecular Formula: C₆H₈ClNO₂
• Molecular Weight: 161.58622
• EINECS: 255-266-2
• Mol File: 41212-96-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 310.1 °C at 760 mmHg
• Flash Point: 141.4 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.000612mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-chloroethyl)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)pyrrolidine-2,5-dione(41212-96-8)
• EPA Substance Registry System: 1-(2-chloroethyl)pyrrolidine-2,5-dione(41212-96-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 41212-96-8(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)pyrrolidine-2,5-dione, also known as carmustine, is a chemotherapy medication used to treat certain types of brain tumors, leukemia, lymphoma, and multiple myeloma. It belongs to the class of alkylating agents, which work by interfering with the DNA replication process of cancer cells, ultimately leading to their death. Carmustine is administered intravenously and is often used in combination with other chemotherapy drugs. It has been shown to be effective in slowing the progression of certain cancers and improving survival rates. However, it also carries a risk of side effects such as bone marrow suppression, increased susceptibility to infections, and kidney damage. Therefore, its use must be carefully monitored and managed by healthcare professionals.

InChI:InChI=1/C6H8ClNO2/c7-3-4-8-5(9)1-2-6(8)10/h1-4H2

Upstream product

• 123-56-8 Succinimide 
• 107-04-0 1-Bromo-2-chloroethane 
• 107-07-3 2-chloro-ethanol 
• 107-06-2 1,2-dichloro-ethane 
• 128-09-6 N-chloro-succinimide 
• 74-85-1 ethene 

Relevant articles and documents

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A Thiophene Analogue of Praziquantel, and Related Systems, by Intramolecular Cyclisation of Acyliminium Salts

N--succinimide (7a) and -glutarimide (7b) on reduction with sodium borohydride in methanol at -10 deg C yield the respective hydroxylactams which on treatment with formic acid cyclise via the intermediate acyliminium ions to 4,5,9,9a-tetrahydropyrrolothienopyridin-7-one (9a) and 4,5,8,9,10,10a-hexahydropyridothienopyridin-7-one (9b) respectively.In a similar manner, 4-cyclohexylcarbonyl-1-piperazine-2,6-dione (11) is converted into the thiophene isostere (2) of praziquantel (1).Likewise, formic acid induced cyclisations of the hydroxylactams derived from N-- (16) and N-succinimide (19) furnish 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (18) and 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (21), respectively.

Acylation of bis(2 chloroethyl)amine (nitrogen mustard)

The preparation is described of N,N bis [2 chloroethyl] amides of fatty and keto acids, of N,N bis [2 chloroethyl] amino acids and of N [2 chloroethyl] imides and amides as potential cytostatic agents.