41223-92-1

Usage

Uses

Used in Pharmaceutical Industry:
1H-TETRAZOLE-1-ACETYL CHLORIDE is used as a reagent in the synthesis of various pharmaceutical compounds. Its reactive nature allows for the formation of new chemical bonds, facilitating the creation of complex molecules with potential therapeutic applications.
Used in High-Performance Polymer Industry:
1H-TETRAZOLE-1-ACETYL CHLORIDE is used as a reagent in the production of high-performance polymers. Its ability to participate in chemical reactions enables the development of advanced materials with unique properties, such as enhanced strength, durability, and resistance to environmental factors.
In both industries, 1H-TETRAZOLE-1-ACETYL CHLORIDE is used for its ability to facilitate chemical reactions, leading to the creation of new compounds and materials with specific properties and applications. Its reactive nature makes it a valuable component in the development of innovative products in pharmaceuticals and high-performance polymers.

Upstream product

• 21732-17-2 1H-tetrazol-1-ylacetic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1417914-62-5 N-(2-(2-(2'-(2-(2-(2-oxo-2-(1H-1,2,3,4-tetrazol-1-yl)ethylamino)ethylthio)ethoxy)biphenyl-2-yloxy)ethylthio)ethyl)-2-(1H-1,2,3,4-tetrazol-1-yl)acetamide 
• 1412945-40-4 C₁₉H₁₉ClN₆O₅S 
• 92628-47-2 2-[(3S,4R)-3-(tert.-butyl-dimethyl-silyloxymethyl)-4-[2-(tetrazol-1-yl)-acetylthio]-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester 
• 179035-65-5 benzhydryl 7β-[2-(1-tetrazolyl)acetamido]-3-(1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylate 
• 75670-03-0 (6R,7S)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-(2-tetrazol-1-yl-acetylamino)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 57079-51-3 (6R)-3-(2-ethoxycarbonyl-vinyl)-8-oxo-7t-(2-tetrazol-1-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Abstract Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs. Here we describe the discovery of a novel class of indole inhibitors, identified through focused screening of 42,000 compounds and evaluated using a series of hit validation assays that included fluorescence polarization binding, 1D NMR, ITC and chromogenic enzymatic assays. Compounds with low nanomolar potency, favorable physico-chemical properties and inhibitory activity in human mast cells have been identified. In addition, our studies suggest that the active site of hH-PGDS can accommodate larger structural diversity than previously thought, such as the introduction of polar groups in the inner part of the binding pocket.

METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES

The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo- oxidoreductase inhibitor to a subject in need of treatment thereof.

studies on anti-helicobacter pylori agents. Part 2: New cephem derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of cephem derivatives are described. Introduction of thio-heterocyclic groups containing N- and S-atoms to the 3-position and phenyl or thienyl acetamido groups to the 7-position of the cephem nucleus dramatically improved the activity. From this series of derivatives, compound 13i was found to have extremely potent in vitro anti-H. pylori activity, superior therapeutic efficacy compared to AMPC and CAM, no cross-resistance between CAM or MNZ and low potential for causing diarrhea due to instability to β-lactamase. Copyright (C) 2000 Elsevier Science Ltd.

Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 2. Effect of side-chain modification on in vitro activity and pharmacokinetic parameters

The structure-activity relationship among a series of novel pyrazolidinone antibacterial agents is described. Specifically, the effect of modification of the side chain attached to the nitrogen at C-7 was explored in an attempt to improve the potency and spectrum of activity. This approach was successful in identifying several compounds having good in vitro profiles. These top candidates were then evaluated for their activity in vivo, and their pharmacokinetic behavior in various animal models was explored. This information proved critical for the identification of candidates for clinical evaluation.

1-Oxacephalosporins: Enhancement of β-Lactam Reactivity and Antibacterial Activity

The effect of replacement of sulfur in the cephem nucleus by oxygen upon the β-lactamase stability, infrared carbonyl frequency of the β-lactam ring, and antibacterial activity was investigated.The replacement reduced the stability of β-lactam compounds t

Δ2,3 -1,4-MORPHOLINE-2-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF USEFUL IN PREPARATION OF ANTIBACTERIA AGENTS

There is described novel substituted Δ2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula STR1 wherein Q is hydrogen or alkyl and X is amino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are useful as intermediates in the preparation of antibacterial agents.