41231-25-8

Upstream product

• 131356-52-0 2,2-dibromo-1-(4-cyanophenyl)ethene 
• 677-22-5 tert-butylmagnesium chloride 
• 3032-92-6 4-cyanophenylacetylene 
• 630-19-3 pivalaldehyde 
• 917-92-0 3,3-Dimethylbut-1-yne 
• 3058-39-7 4-iodobenzonitrile 
• 74215-24-0 4-((2R,3S)-3-tert-Butyl-4-oxo-oxetan-2-yl)-benzonitrile 

Relevant academic research and scientific papers

Cu-mediated or metal-free alkylation of gem-dibromoalkenes with tertiary, secondary and primary alkyl Grignard reagents

A novel copper-mediated or transition-metal-free alkylation of gem-dibromoalkenes with tertiary, secondary and primary alkyl Grignard reagents was described. The outcomes of these reactions were found to be highly dependent on the reaction conditions and

Copper- and Nickel-Catalyzed Cross-Coupling Reaction of Monofluoroalkenes with Tertiary, Secondary, and Primary Alkyl and Aryl Grignard Reagents

A highly efficient cross-coupling reaction of monofluoroalkenes with tertiary, secondary, and primary alkyl and aryl Grignard reagents in the presence of a catalytic amount of copper or nickel catalyst, respectively, has been developed. The reactions proceeded smoothly at room temperature, providing (E)-alkene isomers in moderate to high yields. Plausible mechanisms of the Ni-catalyzed coupling reaction of monofluoroalkene with Grignard reagents are suggested.

Metal-Free Oxidative Decarbonylative Hydroalkylation of Alkynes with Secondary and Tertiary Alkyl Aldehydes

A new, metal-free, radical-mediated oxidative decarbonylative hydroalkylation of various alkynes with secondary and tertiary alkyl aldehydes using di-tert-butyl peroxide (DTBP) as oxidant is presented. This method enables the simultaneous formation of a C C bond and a C H bond through a sequence of decarbonylation, radical addition and protonation, and provides a straightforward route for transforming alkynes into alkenes with high compatibility with both alkynes and alkyl aldehydes. (Figure presented.) .

The first example of hydrozirconation of alkynes in room temperature ionic liquids

Hydrozirconation of terminal alkynes in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) at 30 °C gave highly regio- and stereoselectively (E)-vinylzirconium complexes, which underwent a cross-coupling reaction with aryl halides in the presence of Pd(PPh 3)4 to afford (E)-1,2-disubstituted ethenes in good to high yields. Our system not only avoids the use of easily volatile THF or CH2Cl2 as solvent but also solves the basic problem of palladium catalyst reuse.

Studies on the 1,2-migrations in Pd-catalyzed negishi couplings with JosiPhos ligands

(Chemical Equation Presented) We report an initial investigation with the goal of determining the factors that control the 1,2-migration in the Negishi cross-coupling, which is promoted by palladium catalyst systems generated with JosiPhos ligands. Severa

HAMMETT-CORRELATIONS, SOLVENT EFFECTS AND STEREOCHEMISTRY OF THE THERMAL DECARBOXYLATION OF 2-OXETANONES - EVIDENCE FOR A ZWITTERIONIC INTERMEDIATE

Kinetic and stereochemical data of the thermal decarboxylation of 2-oxetanones (1 and 2) indicate that the reaction proceeds via a zwitterionic intermediate Z.