131356-52-0

Upstream product

• 558-13-4 carbon tetrabromide 
• 105-07-7 4-cyanobenzaldehyde 
• 109-99-9 tetrahydrofuran 
• 157729-39-0 4-(2-bromoethynyl)-benzonitrile 

Downstream Products

• 29822-79-5 4-(2-phenylethynyl)benzonitrile 
• 79149-50-1 2-(4-cyanophenyl)-1-(piperidin-1-yl)ethanone 
• 79149-49-8 4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)benzonitrile 
• 793682-51-6 2-(4-cyanophenyl)methylimidazole 
• 60606-71-5 (E)-1-(4'-cyanophenyl)-2-bromoethylene 
• 92-52-4 biphenyl 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 62856-06-8 4-[2-(4-methylphenyl)ethynyl]benzonitrile 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 56982-37-7 4-[(4-methoxyphenyl)ethynyl]benzonitrile 
• 1206482-99-6 4-(5-phenyl-oxazol-2-ylethynyl)-benzonitrile 
• 27973-41-7 4-((9H-fluoren-9-ylidene)methyl)benzonitrile 
• 60592-58-7 (Z)-4-(2-bromovinyl)benzonitrile 
• 1430102-55-8 4-(m-tolylbuta-1,3-diyn-1-yl)benzonitrile 

Relevant academic research and scientific papers

A Radical-Initiated Fragmentary Rearrangement Cascade of Ene-Ynamides to [1,2]-Annulated Indoles via Site-Selective Cyclization

Straightforward access to [1,2]-annulated indoles, key substructures in natural products, is highly desirable yet challenging. Herein, a radical triggered fragmentary cyclization cascade reaction of ene-ynamides is presented, providing a rapid access into [1,2]-annulated indoles by an intermolecular radical addition, intramolecular cyclization, desulfonylative aryl migration, and site-selective C(sp2)-N cyclization sequence. DFT calculations support oxidation of N-centered radical species to cations prior to the C-N bond formation, followed by an unusual aza-Nazarov cyclization.

Pd-Catalyzed Indole Synthesis via C-H Activation and Bisamination Sequence with Diaziridinone

This work describes an efficient Pd-catalyzed indole synthesis. A wide variety of indoles can be obtained in good yields from readily available vinyl bromides. The reaction likely proceeds through a sequential aryl C-H activation and bisamination of a resulting pallada(II)cycle with diaziridinone.

N -tert-butyl -2 -phenylindole derivative Preparation method and application

The invention belongs to the technical field of organic synthesis, and particularly relates to N - tert-butyl -2 -phenyl indole derivatives as well as a preparation method and application thereof. The preparation method comprises the following steps: (Z)-1 - bromo -1 - phenyl -2 - styrene derivative, N, N - di-tert-butyl diazepinone, palladium catalyst, monophosphine ligand, hydrocarbon activator, base and first solvent, and N -tert-butyl -2 -aryl indole derivatives which can synthesize substituent type diversity, and the prepared N -tert-butyl -2 -aryl indole derivative can be used for preparing biologically active molecules N -2 .

The hydrodebromination of 1,1-dibromoalkenes via visible light catalysis

Vinyl bromides are versatile synthetic intermediates and widely applied in organic synthesis and pharmaceuticals. Herein, a hydrodebromination reaction of 1,1-dibromoalkenes was established via visible light catalysis. A variety of structurally different vinyl bromides were obtained in moderate to excellent yields.

Visible-Light-Induced Alkynylation of α-C–H Bonds of Ethers with Alkynyl Bromides without External Photocatalyst

A direct alkynylation of C(sp3)–H bonds adjacent to an oxygen atom of ethers under visible light irradiation was developed in the absence of an external photocatalyst. The reaction of ethers and alkynyl bromides underwent smoothly to generate the corresponding products in good yields with excellent functional-group tolerance. Initial mechanistic experimental results indicated that the reaction may involve a free radical pathway.

Cs2CO3-Mediated Vicinal Thiosulfonylation of 1,1-Dibromo-1-Alkenes with Thiosulfonates: An Expedient Synthesis of (E)-1,2-Thiosulfonylethenes

A new and highly efficient vicinal thiosulfonylation of 1,1-dibromo-1-alkenes with thiosulfonates in the presence of cesium carbonate has been developed. The metal-free diheterofunctionalization is an operationally simple to access a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields with high levels of stereoselectivities. Further, scalable reactions have been demonstrated for this transformation, thus illustrating its efficiency and practicality. (Figure presented.).

Construction of Phenanthrenes and Chrysenes from β-Bromovinylarenes via Aryne Diels-Alder Reaction/Aromatization

A highly efficient transition-metal-free general method for the synthesis of polycyclic aromatic hydrocarbons like phenanthrenes and chrysenes (and tetraphene) from β-bromovinylarenes and arynes has been developed. The reactions proceed via an aryne Diels-Alder (ADA) reaction, followed by a facile aromatization. This is the first report on direct construction of chrysenes (and tetraphene) using the ADA approach. Unlike the literature method which is limited to only 9/10-substituted derivatives, this method gives access to a wide variety of functionalized phenanthrenes.

Visible Light-Catalyzed Decarboxylative Alkynylation of Arenediazonium Salts with Alkynyl Carboxylic Acids: Direct Access to Aryl Alkynes by Organic Photoredox Catalysis

A convenient method mediated by photoredox catalysis is developed for the direct construction of aryl alkynes. Readily available aromatic diazonium salts have been utilized as the aryl radical source to couple alkynyl carboxylic acids to feature the decarboxylative arylation. A wide range of substrates are amenable to this protocol with broad functional group tolerance, and diversely-functionalized aryl alkynes could be synthesized under mild, neutral and transition metal-free reaction conditions using visible light irradiation. Alongside synthetic sustainability associated with the photocatalytic and transition metal-free operation, another key point of this method is that the organic dye catalyst acts as an excited-state reductant, thus establishing the quenching cycle for radical addition and decarboxylative elimination. (Figure presented.).

PHOTOISOMERIZABLE DIPHENYLDIACETYLENE-AZOBENZEN MESOGENS AND POLYMERS THERE OF

The present invention relates to an azobenzene compound, a hologram recording composition containing the same, a hologram recording medium, a hologram recording material using the same, and a hologram recording or rewriting method. The azobenzene monomer

PYRROLE DERIVATIVES AS PLK1 INHIBITORS

The invention provides compounds of the formula (3): or a pharmaceutically acceptable salt or tautomer thereof. The compounds are useful in the treatment of cancers.