412339-09-4Relevant academic research and scientific papers
Copper-mediated intramolecular aza-Wacker-type cyclization of 2-alkenylanilines toward 3-aryl indoles
Yang, Rui,Yu, Jin-Tao,Sun, Song,Zheng, Qingheng,Cheng, Jiang
, p. 445 - 448 (2017/01/11)
A copper-mediated intramolecular aza-Wacker-type cyclization was developed for the direct and efficient synthesis of 3-aryl indoles using 2-alkenylanilines in moderate to good yields with good functional group compatibility. This strategy shows the high efficiency, operational simplicity as well as broad substrate scope.
Synthesis of Indoles from 2-Vinylanilines with PIFA or TFA and Quinones
Wu, Mingzhong,Yan, Rulong
supporting information, p. 729 - 733 (2017/03/21)
The cyclizations involved in the synthesis of different indoles from 2-vinylanilines with PIFA {[bis(trifluoroacetoxy)iodo]benzene} and quinones have been developed under mild conditions. Various substituents on 2-vinylanilines induced good compatibility and gave the desired products in moderate to good yields.
A general, regioselective approach to the synthesis of ortho allylanilines
Harmata, Michael
, p. 4769 - 4772 (2007/10/02)
Readily available 2,1-benzothiazines can be alkylated via deprotonation with butyllithium followed by treatment with iodomethyltrimethylsilane. Subsequent treatment with fluoride and hydrolysis leads to ortho allyl anilines in high yield. The reaction is general and regioselective by virtue of these characteristics being present in the Lewis acid mediated reaction of alkenes and sulfonimidoyl chlorides, the reaction which leads to the 2,1-benzothiazines used as starting materials.
