412357-32-5

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate is used as a key building block for the production of peptides and small molecules with potential drug properties. Its protecting group function allows for efficient peptide synthesis, facilitating the creation of complex organic compounds and contributing to the development of new pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate is used as a reagent in various chemical reactions. Its unique structural features make it a versatile component in the synthesis of a wide range of organic compounds.
Used in Medicinal Chemistry and Drug Discovery:
tert-butyl 4-(1,3-dioxoisoindolin-2-yl)piperidine-1-carboxylate's structural attributes also make it a valuable tool in medicinal chemistry and drug discovery. It can be employed to explore and develop new therapeutic agents, enhancing the understanding of molecular interactions and contributing to the advancement of pharmaceutical research.

Upstream product

• 85-44-9 phthalic anhydride 
• 108-24-7 acetic anhydride 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 1074-82-4 potassium phtalimide 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 136918-14-4 phthalimide 

Relevant academic research and scientific papers

HYDRAZINE COMPOUND AS BLOOD COAGULATION FACTOR Xa INHIBITOR

Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or its phenyl ring, and a 4-10 membered heterocyclic ring or its benzo ring; Y and Z are independently selected from 4-9 membered saturated heterocyclic rings respectively; RI-3 are independently selected from H, F, Cl, Br, I, CN, OH, SH,NH2, CHO, COOH respectively, or selected from C1-10 alkyls or heteroalkyls optionally substituted by R01, C3-10 alkyls ring hydrocarbon groups or heterocyclic hydrocarbon groups, C1-10 alkyls or heteroalkyls substituted by C3-10 ring hydrocarbon groups or heterocyclic hydrocarbon group. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation Xa.

THERAPEUTIC AGENT FOR CEREBRAL INFARCTION

The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.

AMINE SUBSTITUTED PIPERIDINE MELANOCORTIN RECEPTOR-SPECIFIC COMPOUNDS

A compound of the formula I, where R1, R2a, R2b, R3, L1, L2, Q, J, X, m and n are as defined, or an enantiomer, stereoisomer or diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, and the use thereof in the treatment of diseases, syndromes and conditions.

NITROGENOUS FIVE-MEMBERED RING COMPOUNDS

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I] : wherein symbols in the formula have the following meanings;A: -CH2- or -S-,B: CH or N,R1: H, a lower alkyl group, etc.,X: a single bonding arm, -CO-, -Alk-CO-, -COCH2-, -Alk-O-, -O-CH2-, -SO2-, -S-, -COO-, -CON(R3)-, -Alk-CON(R3)-, -CON(R3)CH2-, -NHCH2-, etc.,R3: hydrogen atom or a lower alkyl group,Alk: a lower alkylene group, andR2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is -CO-, then B is N, or a pharmaceutically acceptable salt thereof.

Removable phosphine reagents for the Mitsunobu reaction

We have developed a novel triphenylphosphine replacement for the Mitsunobu reaction. We have demonstrated that 4-diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester (DPPBE) is an efficient reagent and greatly facilitates the isolation of the desired product.