41240-73-7Relevant academic research and scientific papers
DINUCLEOTIDE COMPOUNDS FOR HCV INFECTION
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Paragraph 0373; 0374, (2014/05/07)
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds comprise two 2′-methyl nucleotides linked according to Formula I: [in-line-formulae]N1-L-N2??(I)[/in-line-formulae] or a pharmaceutically acceptable salt, ester, solvate, stereoisomer, isomeric form, tautomeric form or polymorphic form thereof; wherein N1, L and N2 are as described herein.
Geometrical photoisomerization of (Z)-cyclooctene sensitized by aromatic phosphate, phosphonate, phosphinate, phosphine oxide and chiral phosphoryl esters
Shi, Min,Inoue, Yoshihisa
, p. 2421 - 2427 (2007/10/03)
Aromatic phosphate, phosphonate, phosphinate and phosphine oxide have been used as effective sensitizers for the geometrical photoisomerization of (Z)-cyclooctene (1Z) to its highly strained (E)-isomer (1E). Photosensitizations with phosphate and phosphonate gave moderate photostationary-state E/Z ratios of 0.14-0.17. A comparative study of the fluorescence quenching experiments and kinetic analysis of the product yield demonstrate that the photosensitized isomerization proceeds through a mixed mechanism that involves both singlet and triplet excited states. Triphenylphosphine oxide is not fluorescent and gave a low photostationary-state E/Z ratio of 0.05. Using (-)-menthyl or (-)-bornyl phosphate, phosphonate and phosphinate as chiral sensitizers, the enantiodifferentiating photoisomerization of 1Z was performed to afford optically active 1E in enantiomeric excesses ≤5%.
