41252-79-3

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL is utilized in the production of pesticides, fungicides, and herbicides. Its chemical properties make it an effective ingredient in these products, helping to protect crops and enhance agricultural productivity.
Used in Chemical Reactions:
2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL serves as a solvent or intermediate in various chemical reactions. Its reactivity and stability make it a valuable component in the synthesis of other compounds, contributing to the chemical industry's ability to create new and innovative products.
However, it is crucial to handle 2-CHLORO-2-(4-CHLORO-PHENYL)-ETHANOL with care due to its potential toxicity to aquatic organisms and its ability to cause skin and eye irritation in humans. Proper safety measures should be taken to minimize any adverse effects on the environment and human health.

InChI:InChI=1/C8H8Cl2O/c9-7-3-1-6(2-4-7)8(10)5-11/h1-4,8,11H,5H2

Upstream product

• 2788-86-5 4-Chlorostyrene oxide 
• 104-88-1 4-chlorobenzaldehyde 
• 7477-64-7 1-(p-chlorophenyl)-1,2-ethanediol 
• 7138-34-3 p-chloromandelic acid 

Downstream Products

• 58369-61-2 2-chloro-2-(4-chlorophenyl)acetaldehyde 
• 10465-91-5 3-(4-chlorophenyl)-2H-chromen-2-one 

Relevant academic research and scientific papers

Selective monochlorination of unsymmetrical vicinal diols with chlorinated iminium chlorides

Chlorinated iminium chlorides have been identified to promote the highly efficient and selective mono-chlorination of unsymmetrical vicinal diols. Vilsmeier reagent, namely, (chloromethylene)dimethyliminium chloride, enables highly reactive and regioselective chlorination of 1,2- and 1,3-diols featured one secondary benzylic hydroxy group and one primary aliphatic hydroxy group to give the corresponding 1,2- and 1,3-chlorohydrins. Viehe's salts (α,α-dichloro iminium salts) exhibit excellent reactivity and good selectivity for vicinal diols to give the corresponding chlorohydrin carbamates via a cyclic intermediate in situ. The chlorination protocols tolerate diverse functional groups, including halogens, naphthalene rings, nitro, and cyano. Moreover, the optical purity of chiral diols could be retained during this chlorination reaction.

Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes

The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3-arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.

Facile and regioselective conversion of epoxides into β-chlorohydrins using ZrCl4

Epoxides were efficiently converted into the corresponding β-chlorohydrins in good yields by treatment with ZrCl4 in acetonitrile.