10465-91-5

Basic information

• Product Name: 3-(4-chlorophenyl)chromen-2-one
• Synonyms: 3-(4-chlorophenyl)chromen-2-one
• CAS NO: 10465-91-5
• Molecular Formula: C₁₅H₉ClO₂
• Molecular Weight: 256.68
• Mol File: 10465-91-5.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 426.5°Cat760mmHg
• Flash Point: 233.2°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 1.77E-07mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 3-(4-chlorophenyl)chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)chromen-2-one(10465-91-5)
• EPA Substance Registry System: 3-(4-chlorophenyl)chromen-2-one(10465-91-5)

Safety Data

• Hazardous Substances Data: 10465-91-5(Hazardous Substances Data)

Usage

General Description

3-(4-chlorophenyl)chromen-2-one, also known as 4-Chloroisobenzofuran-1(3H)-one, is a chemical compound with a molecular formula C15H9ClO2. It is a derivative of coumarin, a naturally occurring compound found in many plants. 3-(4-chlorophenyl)chromen-2-one has been investigated for its potential pharmacological properties, including its anti-inflammatory, antioxidant, and anticancer activities. It has also been studied for its potential use in the development of new drugs for various medical conditions. The compound is characterized by its chromen-2-one structure with a chlorine substituent at the 4-position of the phenyl ring, which contributes to its unique properties and potential biomedical applications.

InChI:InChI=1/C15H9ClO2/c16-12-7-5-10(6-8-12)13-9-11-3-1-2-4-14(11)18-15(13)17/h1-9H

Upstream product

• 2028-74-2 p-chlorobenzenediazonium chloride 
• 91-64-5 coumarin 
• 1878-66-6 4-chlorophenylacetic Acid 
• 90-02-8 salicylaldehyde 
• 92-45-5 3-chloro-2H-chromen-2-one 
• 1679-18-1 4-Chlorophenylboronic acid 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 4998-15-6 4-chlorophenylglyoxal 
• 73720-02-2 Z-α-p-chlorophenyl-β-phenylacrylic acid 
• 100-52-7 benzaldehyde 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 
• 1333483-16-1 N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 69976-31-4 3-(2,4-dichlorophenyl)-2H-chromen-2-one 

Relevant articles and documents

A convenient synthesis of 3-arylcoumarins from arylacetonitriles

The condensation of salicylaldehydes with various arylacetonitriles catalyzed by anion-exchange resins such as Amberlite IRA 900, leads to the corresponding 3-arylcoumarins in good yields and selectivity.

Dual Role of Oxoaldehydes: Divergent Synthesis of 3-Aryl- and 3-Aroylcoumarins

A facile and efficient synthetic approach to various valuable 3-aryl- and 3-aroylcoumarins by the direct arylation and aroylation of coumarins with glyoxals in a metal-free manner is presented. The aryl glyoxal is for the first time recognized to serve as an aryl surrogate in addition to its role as an aroyl transfer reagent via a simple switch in reaction conditions. The approach accommodates a broad substrate scope and high yields of the two types of cross-coupling reactions starting from identical starting materials.

Combatting AMR: A molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Antimicrobial resistance (AMR) is a major emerging threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. While the problem escalates, lack of financial incentive has lead major pharmaceutical co

Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides using N-formylsaccharin as a CO surrogate

A convenient and highly efficient Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides to afford the corresponding 3-arylcoumarins in good to excellent yields has been developed. Importantly, the protocol utilizes a commercially available, low cost, solid and easy to handle N-formylsaccharin as an alternative to the highly toxic CO gas.