41266-63-1Relevant academic research and scientific papers
Tetrahydro pyridine [4, 3 - b] antithetical indole compounds, its preparation method and medical use
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Paragraph 0029-0031, (2017/07/13)
The invention discloses a tetrahydropyridine [4,3-b] diindyl compound, as well as a preparation method and a pharmaceutical application thereof. The structure formula of the tetrahydropyridine [4, 3-b] diindyl compound is shown in a formula (A), wherein R1 is 7,8 disubstituted alkyl, 6 or 8 substituted halogen and alkoxy 8 substituted; R2 is 2 substituted alkoxy; n is 1 or 2. The invention further discloses a preparation method of the tetrahydropyridine [4, 3-b] diindyl compound and an application in preparation of a medicine for treating benign prostatic hyperplasia and lower urinary tract syndromes caused by the benign prostatic hyperplasia.
Synthesis of 8-substituted tetrahydro-γ-carbolines
Bridoux, Alexandre,Goossens, Laurence,Houssin, Raymond,Henichart, Jean-Pierre
, p. 571 - 578 (2007/10/03)
The Fischer reaction is applied to the synthesis of 8-substituted tetrahydro-γ-carbolines with electron-donating or electron-withdrawing groups, using catalytic or thermal methods. The reaction conditions must be varied according to the nature of the N 1 substituent of the piperidone. The best results are observed when a releasing group is present on the arylhydrazine and a benzyl substituent on the nitrogen of piperidone. Formation of carbolines with a withdrawing substituent is observed in soft acidic conditions; in others, reaction ended at the hydrazone level or did not evolve.
