41266-64-2

Basic information

• Product Name: 5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one(SALTDATA: FREE)
• Synonyms: 5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one(SALTDATA: FREE);5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one
• CAS NO: 41266-64-2
• Molecular Formula: C₇H₈N₄O
• Molecular Weight: 164.16462
• Mol File: 41266-64-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one(SALTDATA: FREE)(41266-64-2)
• EPA Substance Registry System: 5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one(SALTDATA: FREE)(41266-64-2)

Safety Data

• Hazardous Substances Data: 41266-64-2(Hazardous Substances Data)

Upstream product

• 23906-13-0 2-hydrazino-4,6-dimethylpyrimidine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 75-44-5 phosgene 

Relevant articles and documents

GPR139 RECEPTOR MODULATORS

Compounds are provided that modulate the GPR139 receptor, compositions containing the same, and to methods of their preparation and use for treatment of a malcondition wherein modulation of the GPR139 receptor is medically indicated or beneficial. Such compounds have the structure of Formula (X) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, R3, R4, R9, R10, R11, and R12, Q5, Q6, Q7 and Q8 are as defined herein.

Synthesis, Molecular Structure, and Reactions of 1H-1,2,4-Triazolopyrimidinium Betaines

Novel 1-substituted 1,2,4-triazolopyrimidinium betaines have been prepared and characterised.Treatment of 1-alkyl-1-(4,6-dimethylpyrimidin-2-yl)hydrazines (2f-j) with phosgene gave a series of 1,2,4-triazolopyrimidinium chlorides (3a-e) which were subsequently converted by ammonia into 1,2,4-triazolopyrimidinium-3-olates (5a-e).Analogous 3-thiolates (5g-k) were best synthsized by treating the appropriate hydrazines (2f-j) with carbon disulphide.The 1-(3-hydroxypropyl) derivatives (5f) and (5l) were obtained by deprotection of benzyl derivatives (5e) and (5k) using BCl3 in dichloromethane at -10 deg C.Methylation of the 3-thiolate derivative (5g) with iodomethane gave the salt (9) which was subsequently transformed by methylamine into the triazole derivative (10). 1,5,7-Trimethyl-1H-1,2,4-triazolopyrimidinium-3-thiolate gave 5-amino-1-methyl-1H-1,2,4-triazole-3-thiol (11) on treatment with hydrazine hydrate.The molecular structure of 1-benzyl-5,7-dimethyl-1H-1,2,4-triazolopyrimidinium-3-olate (5b) has been determined by X-ray crystallography.