41282-85-3Relevant academic research and scientific papers
A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines
Liu, Chunjian,Lin, James,Leftheris, Katerina
, p. 435 - 437 (2007)
A novel one-pot procedure for the preparation of N,6-disubstituted-1,3,5-triazine-2,4-diamines and its scope of application are demonstrated with a number of examples. The new procedure involves the treatment of isothiocyanates with sodium hydrogencyanami
2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof
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Paragraph 0028; 0078, (2021/10/05)
The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.
Biguanide-based synthesis of 1,3,5-triazine derivatives with anticancer activity and 1,3,5-triazine incorporated calcium citrate nanoparticles
Chalermnon, Monnaya,Cherdchom, Sarocha,Khotavivattana, Tanatorn,Rojanathanes, Rojrit,Sereemaspun, Amornpun
, (2021/06/12)
Twelve derivatives of biguanide-derived 1,3,5-triazines, a promising class of anticancer agent, were synthesised and evaluated for their anticancer activity against two colorectal cancer cell lines—HCT116 and SW620. 2c and 3c which are the derivatives con
6,: N 2-Diaryl-1,3,5-triazine-2,4-diamines: Synthesis, antiproliferative activity and 3D-QSAR modeling
Chuah, Lay Hong,Dolzhenko, Anton V.,Junaid, Ahmad,Lim, Felicia Phei Lin
, (2020/04/20)
A library of 126 compounds with a 6,N2-diaryl-1,3,5-triazine-2,4-diamine scaffold was prepared using a one-pot, microwave-assisted method from readily available cyanoguanidine, aromatic aldehydes and arylamines. The three-component condensation of these reagents in the presence of hydrochloric acid was followed by the treatment with a base, which promoted a rearrangement of the dihydrotriazine ring and its dehydrogenative aromatization. The antiproliferative properties of the prepared compounds were evaluated using three breast cancer cell lines. The most promising results were obtained in the growth inhibition of the triple negative MDA-MB231 breast cancer cells. The active compounds were also selective against cancer cells and did not affect growth of the non-cancerous MCF-10A breast cell line. Analyzing the structure-activity relationship within the series, we built a 3D-QSAR model for the further design of more potent anticancer compounds.
New one-pot synthesis of 1,3,5-triazines: three-component condensation, dimroth rearrangement, and dehydrogenative aromatization
Junaid, Ahmad,Lim, Felicia Phei Lin,Tiekink, Edward R. T.,Dolzhenko, Anton V.
supporting information, p. 548 - 555 (2019/06/25)
A new, effective one-pot synthesis of the 6,N2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation of cyanoguanidine, aromatic aldehydes, and arylamines in the presence of hydrochloric acid. Without isolation, the resulting 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines were treated with a base to initiate Dimroth rearrangement and spontaneous dehydrogenative aromatization, affording the desired compounds. The developed method was found to be sufficiently general in scope, tolerating various aromatic aldehydes and amines; by using their combinations in the first step, a representative library of 110 compounds was successfully prepared and screened for anticancer properties.
Iridium Supported on Phosphorus-Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction
Yao, Wei,Duan, Zheng-Chao,Zhang, Yilin,Sang, Xinxin,Xia, Xiao-Feng,Wang, Dawei
supporting information, p. 5695 - 5703 (2019/12/30)
Iridium-on-phosphorus-doped porous organic polymers (POP?Ir) were developed by anchoring simple iridium onto the skeleton of porous organic polymers through coordination bonds. This POP?Ir catalyst, which was thoroughly characterized by means of EDS, SEM, TEM, XRD, XPS, and FT-IR, revealed excellent catalytic activity for the reaction of diphenyl phosphinamide with benzyl alcohols through borrowing hydrogen strategy and acceptorless dehydrogenation with wide functional group tolerance. Moreover, this POP?Ir catalyst could be simply recovered and reused for at least five times without a significant loss of activity, and revealed considerable application prospects. The mechanism was investigated to further understand this POP?Ir catalytic system and transformations. Overall, the POP?Ir catalytic system has shown high activity and reusability in the borrowing hydrogen reaction between diphenyl phosphinamides and benzyl alcohols. (Figure presented.).
Ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides
Zeng, Ming,Wang, Tao,Cui, Dong-Mei,Zhang, Chen
supporting information, p. 8225 - 8228 (2016/10/11)
An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities s
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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, (2013/07/19)
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
