ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE
• CAS No.: 41301-66-0
• Molecular Formula: C12H18O5
• Molecular Weight: 242.272
• Hs Code.: 2918990090
• Mol file: 41301-66-0.mol

Synonyms:6G-927;<1-Aethoxycarbonyl-cyclopentan-2-on-1-yl>-essigsaeure-aethylester;ethyl 1-ethoxycarbonyl-2-oxocyclopent-1-ylacetate;

Chemical Property of ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE

Chemical Property:

• PSA: 69.67000
• LogP: 1.24210

Purity/Quality:

99% ^*data from raw suppliers

2-Carbethoxy-2-(carbethoxymethyl)-1-cyclopentanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE

There total 7 articles about ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) + chloroacetic acid ethyl ester (105-39-5) → ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentanecarboxylate (41301-66-0)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

DOI:10.1007/BF00811764

Reference yield: 80.0%

ethyl 2-oxo-cyclopentanecarboxylate potassium salt (40702-70-3) → ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentanecarboxylate (41301-66-0)

Guidance literature:

In N,N-dimethyl-formamide; at 145 - 147 ℃;

Reference yield: 70.0%

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) + ethyl bromoacetate (105-36-2) → ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentanecarboxylate (41301-66-0)

Guidance literature:

DOI:10.1016/S0040-4039(00)92864-8

upstream raw materials:

2-ethoxycarbonyl-1-cyclopentanone

ethyl bromoacetate

diazoacetic acid ethyl ester

ethyl 2-oxo-cyclopentanecarboxylate potassium salt

Downstream raw materials:

(2-oxocyclopent)acetic acid

(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid, L-arginine salt

[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

(R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Refernces

• 1、 Montalban, Antonio Garrido,Ma, You-An,Johannsen, Steve,Tandel, Sagun,Martinelli, Michael J.. "A novel Fischer pseudo-benzylic decarboxylation approach to the 1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl system". . p. 378 - 381. Retrieved 2015.
• 2、 -. "SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS". Page/Page column 51. . Retrieved 2010/04/03.